نتایج جستجو برای: plga nanosphere

تعداد نتایج: 4541  

2013
Changkyu Lee Ji Su Choi Insoo Kim Kyung Taek Oh Eun Seong Lee Eun-Seok Park Kang Choon Lee Yu Seok Youn

Inhalable glycol chitosan-coated poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing palmitic acid-modified exendin-4 (Pal-Ex4) (chitosan Pal-Ex4 PLGA NPs) were prepared and characterized. The surface morphology, particle size, and zeta potential of chitosan Pal-Ex4 PLGA NPs were investigated, and the adsorption and cytotoxicity of chitosan Pal-Ex4 PLGA NPs were evaluated in human lun...

Journal: :Journal of colloid and interface science 2016
Song Yi Lee Eunjae Jung Ju-Hwan Park Jin Woo Park Chang-Koo Shim Dae-Duk Kim In-Soo Yoon Hyun-Jong Cho

Chitosan (CS)-modified poly(d,l-lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) were prepared and their lung targetability after intravenous administration was elucidated. PLGA NPs (mean diameter: 225nm; polydispersity index: 0.11; zeta potential: -15mV), 0.2% (w/v) CS-coated PLGA NPs (CS02-PLGA NPs, mean diameter: 264nm; polydispersity index: 0.17; zeta potential: -7mV), and 0.5% (w/v) CS-...

2014
LIANG XU HUA LI YUBIN WANG FANG DONG HUANGBING WANG SHUTONG ZHANG

Effective chemotherapy remains an important issue in the treatment of drug resistant cancer. The aim of the present study was to establish novel polymeric nanoparticles composed of the antitumor drug, doxorubicin (DOX), and an inhibitor of the drug efflux pump-associated protein, P-glycoprotein (P-gp), in order to overcome drug resistance in tumor cells. Poly(D,L-lactide-co-glycolide) (PLGA), D...

2014
Yong Cheol Shin Won Jun Yang Jong Ho Lee Jin-Woo Oh Tai Wan Kim Jong-Chul Park Suong-Hyu Hyon Dong-Wook Han

This study concentrates on the development of biodegradable nanofiber membranes with controlled drug release to ensure reduced tissue adhesion and accelerated healing. Nanofibers of poly(lactic-co-glycolic acid) (PLGA) loaded with epigallocatechin-3-O-gallate (EGCG), the most bioactive polyphenolic compound in green tea, were electrospun. The physicochemical and biomechanical properties of EGCG...

2017
Ju-Hwan Park Hyun-Jong Cho Dae-Duk Kim

Poly((D,L)lactic-glycolic)acid-star glucose (PLGA-Glc) polymer-based nanoparticles (NPs) were fabricated for tumor-targeted delivery of docetaxel (DCT). NPs with an approximate mean diameter of 241 nm, narrow size distribution, negative zeta potential, and spherical shape were prepared. A sustained drug release pattern from the developed NPs was observed for 13 days. Moreover, drug release from...

2015
Francesca Selmin Francesco Puoci Ortensia I. Parisi Silvia Franzé Umberto M. Musazzi Francesco Cilurzo

This work reports the feasibility of caffeic acid grafted PLGA (g-CA-PLGA) to design biodegradable sterile microspheres for the delivery of proteins. Ovalbumin (OVA) was selected as model compound because of its sensitiveness of γ-radiation. The adopted grafting procedure allowed us to obtain a material with good free radical scavenging properties, without a significant modification of Mw and T...

2016
Jung Sang Cho Jung-Kul Lee Yun Chan Kang

A novel one-dimensional nanohybrid comprised of conductive graphitic carbon (GC)-coated hollow FeSe2 nanospheres decorating reduced graphene oxide (rGO) nanofiber (hollow nanosphere FeSe2@GC-rGO) was designed as an efficient anode material for sodium ion batteries and synthesized by introducing the nanoscale Kirkendall effect into the electrospinning method. The electrospun nanofibers transform...

2015
Yifeng Shen Shaohan Xu Donghua He Sabato D'Auria

A novel europium ligand 2,2',2'',2'''-(4,7-diphenyl-1,10-phenanthroline-2,9-diyl) bis (methylene) bis (azanetriyl) tetra acetic acid (BC-EDTA) was synthesized and characterized. It shows an emission spectrum peak at 610 nm when it is excited at 360 nm, with a large Stock shift (250 nm). It is covalently coated on the surface of a bare silica nanosphere containi free amino groups, using 1-ethyl-...

Journal: :iranian journal of pharmaceutical research 0
nima hamzian medical physics research center, mashhad university of medical sciences, mashhad, iran maryam hashemi nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran mahdi ghorbani medical physics research center, mashhad university of medical sciences, mashhad, iran mohammad hossein bahreyni toosi medical physics research center, mashhad university of medical sciences, mashhad, iran mohammad ramezani pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

the aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates spion and gemcitabine in plga±peg to form multifunctional drug delivery system. for this aim, super paramagnetic iron oxide nanoparticles (spions) were synthesized and encapsulated simultaneously with gemcitabine (gem) in plga±peg copolymers via w/o/w double emulsification method. optimum size and enca...

Journal: :The journal of physical chemistry. B 2006
Zee Hwan Kim Stephen R Leone

An apertureless near-field scanning optical microscope (ANSOM) that utilizes the enhanced field around a gold nanosphere, which is attached to the end of an atomic force microscope (AFM) tip, is used to image the local dielectric constant of the patterned metallic surfaces and local electric field around plasmonic nanosphere samples. A colloidal gold nanosphere (approximately 50 nm diameter) is...

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