pluronic/bile salt/phospholipid mixed micelles (pluronic/bs/ps-mm) drug carrier system for solubilization hydrophobic drugs was developed. a typical hydrophobic compound, pyrene, was selected as a representative hydrophobic compound to model the hydrophobic drugs. five pluronics, f68, f88, f98, f108, and f127 with different ppo chain length were studied. cmc data and solubilization capacities w...

Polymeric micelles are emerging as attractive drug delivery systems. Hydrophobic drugs including photosensitizers for photodynamic therapy can be covalently bound or physically entrapped in the core of the micelles and thus be systemically delivered to, for example, tumors using passive or active targeting strategies. Polymers used for photosensitizer encapsulation include pluronics, poly(ethyl...

This review presents some examples obtained by molecular techniques in the study of non-ionic reverse micelles of poly(ethylene oxide) type surfactants: tetraethylene glycol mono-ndodecyl ether (C12E4), Triton X-100, and triblok copolymers poly(ethylene oxide)-blockpoly(propylene oxide)-blockpoly(ethylene oxide) (L62 and L64 Pluronics). By using specific spectral parameters of spin, fluorescenc...

nimodipine (nm), as a lipophilic calcium channel blocker indicated for the prevention and treatment of neurological disorders, suffers from an extensive first pass metabolism, resulting in low oral bioavailability. polymeric micelles, self-assembled from amphiphilic polymers, have a core-shell structure which makes them unique nano-carriers with excellent performance as drug delivery. this inve...

Improving the printability of paper is still a relevant challenge, despite fast development digital communications. While it well-known that cationic starches enhance ink density, their commercial paper-grade forms are limited to ethers with low degree substitution. This work addresses underexplored potential highly substituted starch for coating and its combination tri-block polymers, namely P...

Temperature sensitive Pluronic (Plu) and pH-sensitive polyacrylic acid (PAA) were successfully mixed in different ratios to form in situ gelling formulations for colon cancer therapy. The major formulations were prepared as the liquid and solid suppository dosage forms. Epirubicin (Epi) was chosen as a model anticancer drug. In vitro characterization and in vivo pharmacokinetics and therapeutic...

Introduction Pluronics, a family of poly(ethylene oxide)-poly(propylene oxide)poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers, are of considerable interest in the biotechnological and pharmaceutical industry for their unique surfactant abilities, low toxicity, and minimal immune response.1 Aqueous solutions of Pluronic copolymers exhibit interesting temperatureinduced aggregation phenome...