results the number of s. pneumoniae isolates resistant to benzylpenicillin, imipenem, oxacillin and ceftazidime were 94.5%, 100%, 100%, and 21.8%, respectively. analysis of mutation in the genes for pbp showed that 85% of isolates had mutations in pbp2x, pbp2b and pbp1a. susceptibility to benzylpenicillin was decreased once the number of mutated pbp genes in s. pneumonia increased. according to...

The aim of the present research was focused on the antibacterial, preliminary phytochemical and pharmacognostical properties of Vicoa indica (L.)DC. via in vitro approach. The aqueous and organic solvent (hexane, chloroform and methanol) extracts from the leaves of Vicoa indica (Asteraceae) were tested against Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Vibrio parahaemolyt...

background and objectives:   many surface proteins are implicated in nasopharyngeal colonization and pathogenesis of streptococcus pneumoniae . some of these factors are candidate antigens for protein based vaccines. new vaccine designs focus on the surface proteins (e. g., pspa and pspc ) and also cytolysin, and pneumolysin. in this study, 3 key virulence genes, lyta , pspc , and rrga , which ...

background: klebseilla pneumoniae causes urinary tract infections, nosocomial pneumonia and intra-abdominal infections. capsular antigens are considered to be the ultimate virulence determinants. among 77 capsular serotypes of k. pneumoniae, serotypes k1 and k2 are the most virulent ones in humans. objectives: we designed a pcr method for detection of capsular serotypes k1 and k2 of k. pneumoni...

background: the increasing pattern of multi-drug resistant (mdr) bacteria has limited therapeutic options especially for nosocomial isolates of klebsiella pneumoniae. therefore, the aim of this study was the molecular detection of 16s rrna methylase and blactx-m-15 among k. pneumoniae strains isolated from hospitalized patients in mofid, imam hossein and taleghani hospitals. materials and metho...

b ackground: in recent decades, extended spectrum beta-lactamase (esbl) producing bacteria have increased worldwide. the most important causative agents of nosocomial infections throughout the world, escherichia coli and klebsiella pneumoniae as main esbl-producing bacteria are so highly regarded. trends  in  the  treatment  of  infections  by such  bacteria  have  led  to  a  global concern. t...

children under 2 years of age suffer from some of the highest rates of invasive pneumococcal disease (ipd) in the world. (turkey) rates of ipd had a decline after statewide introduction of the 7-valent pneumococcal conjugate vaccine (pcv7) in 2008. introduction of pcv7, pcv10 and pcv13 vaccines resulted in elimination of ipd caused by vaccine serotypes, but was followed by increasing rates of i...

results in total, 73 isolates were collected and diagnosed as s. pneumoniae. isolates were susceptible to ofloxacin 95.9%, vancomycin 93%, penicillin 78%, trimethoprim-sulfamethoxazole 61.6%, ceftriaxone 53.5%, meropenem 52%, cefotaxime 46.5%, and erythromycin 8.2%. of the 15 prsp isolates, the pbp2b gene was identified in 12 (80%). in 1 penicillin-intermediate s. pneumoniae isolate the pbp2b w...