Glaucoma is a complex genetic optic disease characterized by a range of optic neuropathies. There are many subtypes of glaucoma but primary open-angle glaucoma (POAG) associated with elevated intraocular pressure (IOP) is the most prevalent form. Based on the age of diagnosis, POAG is categorized as early-onset POAG or juvenile open-angle glaucoma (JOAG) diagnosed between 10 and 35 years and ad...

PURPOSE To investigate the expression level of the optineurin gene (OPTN) in the blood of primary open angle glaucoma (POAG) patients to determine if altered expression is playing a role in primary open angle glaucoma systemically. METHODS Patients (n=47) were eligible for inclusion if they met standard clinical criteria for POAG, including age greater than 40 years, intraocular pressure ≥21 ...

To estimate the rate of visual field progression in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG), we reviewed the medical records of POAG and PACG patients who had a minimum of 5-year longitudinal Goldmann visual field data. I4e and I2e isopters were quantified using grid systems. The rate of change was calculated from the slope of a linear fit to a series of ave...

Primary open angle glaucoma (POAG) is a one of the most common eye diseases in the world, especially in China. Many inflammatory markers are likely to be closely related to the development of POAG, especially cytokines. The aim of our investigation is to reveal the potential association of three interleukin-6 (IL-6) gene SNPs on primary open-angle glaucoma risk factors in Chinese. A case-contro...

glaucoma, a group of multifactor ocular diseases, is the second leading cause of blindness worldwide. primary open angle (poa) is the most common type of glaucoma, characterized by progressive optic nerve degeneration. numerous genes and proteins have been revealed to be associated with poag, but the pathologic mechanisms of the disease are still poorly understood. proteomics, the collective st...

PURPOSE To document the diurnal intraocular pressure (IOP) profile with rebound tonometry performed by primary glaucoma patients in non-clinic environment. PATIENTS AND METHODS Fifty-three medically-treated eyes of 31 primary angle closure glaucoma (PACG) and 22 primary open angle glaucoma (POAG) patients with no previous eye surgery were recruited. Diurnal IOP was measured 5 times per day at...

PURPOSE Myocilin (MYOC) mutations are associated with primary open-angle glaucoma (POAG) in multiple populations. Here we examined the role of MYOC mutations in a black South African population with primary open-angle glaucoma (POAG). METHODS Unrelated black South African subjects with POAG and unaffected controls were recruited from the St. John Eye Hospital (Soweto, Johannesburg, South Afri...

PURPOSE To assess the cortical structure and cerebral blood flow changes in the brain of patients with primary open-angle glaucoma (POAG). METHODS High-resolution anatomical magnetic resonance imaging (MRI) and arterial spin labeling (ASL)-MRI were performed in 23 POAG patients and 29 controls. Patients were further divided into early-moderate and advanced groups based on mean deviation (MD) ...

PURPOSE To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). METHODS Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from an academic hospital-based glaucoma practice. Tear films of recruited patients were obtained and analyzed using a multiplex, high-sensitivity electrochemiluminescent enzyme-li...

BACKGROUND Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear. OBJECTIVE To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD ...