Polymer-peptide conjugates are a promising class of compounds, where polymers can be used to overcome some of the limitations associated with peptides intended for therapeutic and/or diagnostic applications. Linear polymers such as poly(ethylene glycol) can be conjugated through terminal moieties and have therefore limited loading capacities. In this research, functionalised linear poly(ethylen...

The labour market, occupational safety and health, and work organisation are our main fields of activity. The creation and use of knowledge through learning, information and documentation are important to the Institute, as is international cooperation. The Institute is collaborating with interested parties in various development projects. The areas in which the Institute is active include: • la...

Biocompatible magnetic nanoparticles hold great therapeutic potential, but conventional particles can be toxic. Here, we report the synthesis and alternating magnetic field dependent actuation of a remotely controllable, multifunctional nano-scale system and its marked biocompatibility with mammalian cells. Monodisperse, magnetic nanospheres based on thermo-sensitive polymer network poly(ethyle...

Poly(ethylene oxide) (PEO) is one of the most famous polymer electrolytes; however, its low conductivity and capacity have prevented commercial applications. This study utilizes carboxymethyl starch (CMS) oxidized cellulose (OCMC) natural polymers with a high potential to dissolve lithium ions (Li+) in help PEO ionic conductivity. The semi-interpenetrating networks (semi-IPNs) consist crosslink...

A novel polyphosphoester (PPE) with vinyl ether side chain functionality was developed as a versatile template for postpolymerization modifications, and its degradability and biocompatibility were evaluated. An organo-catalyzed ring-opening polymerization of ethylene glycol vinyl ether-pendant cyclic phosphotriester monomer allowed for construction of poly(ethylene glycol vinyl ether phosphotri...

Poly (DL-lactide)/Poly (ethylene glycol) diblock copolymer is successfully synthesized with mPEG and DL-LA as main raw materials, the residual monomers of polymer were removed by recrystallization. FT-IR used to characterize structure polymer. Gas chromatography determine solvent The solubility in different solvents was determined, effect systems on removal discussed. results showed that Poly(D...

A unique hyperbranched polymeric system with a linear poly-2-dimethylaminoethyl methacrylate (pDMAEMA) block and a hyperbranched polyethylene glycol methyl ether methacrylate (PEGMEMA) and ethylene dimethacrylate (EGDMA) block was designed and synthesized via deactivation enhanced atom transfer radical polymerisation (DE-ATRP) for efficient gene delivery. Using this unique structure, with a lin...

Molecular sensing based on plasmonic materials is of great interest not only for basic scientific research but also real-life applications. For sensing, tunable hot-spot generation, in which the electromagnetic field maximized, plays a key role. Herein, we developed platform consisting thermoresponsive polymer brush with colloidal particles and 3-D ordered/vertically aligned gold nanorod (AuNR)...

The delivery of therapeutic peptides and proteins is often challenged by a short half-life, and thus the need for frequent injections that limit efficacy, reduce patient compliance and increase treatment cost. Here, we demonstrate that a single subcutaneous injection of site-specific (C-terminal) conjugates of exendin-4 (exendin) - a therapeutic peptide that is clinically used to treat type 2 d...