Biodegradable four-arm star-shaped poly(lactic acid) (4sPLA) was synthesized from l-Lactic acid (l-LA) and pentaerythritol (PENTA), the polymerization kinetics studied. The effects of reaction time, temperature molar ratio on 4sPLA were discussed. molecular structure characterized by Fourier transform infrared spectroscopy (FTIR) 1H nuclear magnetic resonance spectra (1H-NMR). results showed th...

INTRODUCTION Poly-L-lactic acid (Sculptra, Sanofi Aventis, Bridgewater, NJ) is a gel polymer made of poly-Llactic acid microspheres and water suspended in a mannitol and carboxymethyl cellulose suspension. This injectable tissue filler has been used for correction of lipoatrophy in HIV patients as well as for cosmetic purposes since its US Food and Drug Administration approval in 2004. The mech...

Single crystals of biodegradable aliphatic polyesters, poly([R]-3-hydroxybutyrate), poly([R]-3-hydroxyvalerate), poly(L-lactic acid), poly( -propiolactone), poly(4-hydroxybutyrate), poly(Æ-valerolactone), poly("caprolactone), poly(ethylene succinate) and poly(tetramethylene adipate), were grown from dilute solution by isothermal crystallization, and the crystal structures and morphologies were ...

lactide was synthesized by reverse polymerization of low molecular weight poly(lactic acid) with two different molecular weights:1500 and 2500. two different lactide purification processes such as: recrystallization in ethyl acetate and washing the crude lactide with ether before recrystallization in ethyl acetate were evaluated. it has been demonstrated that increasing the molecular weight of ...

background: disulfiram is oral aldehyde dehydrogenase (aldh) inhibitor that has been used in the treatment of alcoholism. recent studies show that this drug has anticancer properties; however, its rapid degradation has limited its clinical application. encapsulation of disulfiram polymeric nanoparticles (nps) may improve its anticancer activities and protect rapid degradation of the drug. mater...

Lactic acid is one of the top 30 potential building-block chemicals from biomass, of which the most extensive use is in the polymerization of lactic acid to poly-lactic-acid (PLA). To reduce the cost of PLA, the search for cheap raw materials and low-cost process for lactic acid production is highly desired. In this study, the final titer of produced L-lactic acid reached a concentration of 185...

D-configured poly(D-lactic acid) (D-PLA) and poly(D-2-hydroxy-3-methylbutanoic acid) (D-P2H3MB) crystallized separately into their homo-crystallites when crystallized by precipitation or solvent evaporation, whereas incorporation of L-configured poly(L-2-hydroxybutanoic acid) (L-P2HB) in D-configured D-PLA and D-P2H3MB induced co-crystallization or ternary stereocomplex formation between D-conf...

To achieve sustained release of 3-ethyl-4-(4-methylisoxazol-5-yl)-5-(methylthio) thiophene-2-carboxamide (BFB0261), a new potent osteogenic compound for treating bone disorders, we prepared film formulations containing BFB0261 and the following newly synthesized biodegradable polymers by a solvent casting technique: poly(D,L-lactic acid) (PLA), poly(D,L-lactic acid-co-glycolic acid) (PLGA), pol...

Abstract Poly(lactic acid)/poly(butylene adipate- co -terephthalate) with a content ratio of 90/10, and its calcium carbonate (CaCO 3 ) composites nano- micro-sized particles were prepared by melt mixing. The dependence thermal mechanical properties the on particle size addition CaCO filler was investigated. composite containing five parts (abbreviated as 90 L 10 B 5m C, similarly hereinafter) ...