Light scattering and small-angle neutron scattering experiments were performed on comicelles of several combinations of oppositely charged (block co)polymers in aqueous solutions. Fundamental differences between the internal structure of this novel type of micelle --termed complex coacervate core micelle (C3Ms), polyion complex (PIC) micelle, block ionomer complex (BIC), or interpolyelectrolyte...

One of the major obstacles that delay the clinical translation of polymeric micelle drug delivery systems is whether these self-assembled micelles can retain their integrity in blood following intravenous (IV) injection. The objective of this study was to evaluate the impact of core functionalization on the thermodynamic and kinetic stability of polymeric micelles. The combination of ring-openi...

Polymeric micelle of the A₃B-type lactosome comprising (poly(sarcosine))₃-b-poly(l-lactic acid) was labeled with 111In. The 111In-labeled A₃B-type lactosome was administered to the model mice bearing meningeal dissemination and bone metastasis at mandible. With single-photon emission computed tomography (SPECT) imaging, the meningeal dissemination was identified successfully by 111In-labeled A₃...

The effect of hydrocarbon chain length on chemical selectivity in micellar electrokinetic chromatography (MEKC) was investigated using polymeric sulfated surfactants: poly-(sodium 7-octenyl sulfate), poly(sodium 8-nonenyl sulfate), poly(sodium 9-decenyl sulfate), and poly(sodium 10-undecenyl sulfate). Linear solvation energy relationships (LSERs) and free energy of transfer studies were conduct...

Origanum vulgare var. essential oil (OEO) is known as a natural product with multiple beneficial effects application in dermatology. Oregano represents potential therapeutic alternative for fibroepithelial polyps (FPs), commonly skin tags. Innovative formulations have been developed to improve the bioavailability and stability of oils. In this study, we aimed evaluate morphology polymeric-micel...

A water-insoluble antitumor agent, camptothecin (CPT) was successfully incorporated into polymeric micelles formed from poly(ethylene glycol)-poly(benzyl aspartate) block copolymers (CPT-loaded polymeric micelles). Antitumor effects and biodistribution of CPT-loaded micelles were evaluated in mice subcutaneously transplanted by colon 26 tumor cells. Tumor growth was significantly inhibited afte...