Heterotrimeric G proteins of the Gα(i) family have been implicated in signaling pathways regulating cell migration in immune diseases. The Gα(i)-protein-coupled C5a receptor is a critical regulator of IgG FcR function in experimental models of immune complex (IC)-induced inflammation. By using mice deficient for Gα(i2) or Gα(i3), we show that Gα(i2) is necessary for neutrophil influx in skin an...

............................................................. 4 POPULÄRVETENSKAPLIG SAMMANFATTNING............ 5 ABBREVIATIONS...................................................... 6 BACKGROUND......................................................... 8 INFLAMMATION.......................................................... 8 POLYMORPHONUCLEAR GRANULOCYTES................... 9 CAPTURE AND EXTRAVA...

In adult rats, 50,000 units of recombinant interleukin-1 beta (IL-1 beta) injected into the brain parenchyma produced an intense meningitis and disruption of the blood-CSF barrier by 4 h. No increase in vascular permeability to horseradish peroxidase or leukocyte recruitment was observed at the site of injection. By contrast, in juvenile rats, 100 units of IL-1 beta injected into the striatum g...

This study aimed to compare the caspofungin immunomodulating activities against Candida albicans on polymorphonuclear cells (PMNs) from renal transplant recipients (RTRs) and healthy subjects (HSs). RTR PMNs showed a significantly reduced fungicidal activity compared with that of HS PMNs. Addition of caspofungin to RTR PMNs significantly potentiated the yeast intracellular killing rate, achievi...

Characteristics of neonatal neutrophils Polymorphonuclear neutrophils (PMN) are key components of the innate immune system, provide first line immune defence mechanisms against pathogenic challenge, and are both quantitatively and qualitatively deficient in neonates. Neutrophil deficiencies contribute significantly to the increased susceptibility of neonates to serious and overwhelming bacteria...

Polymorphonuclear leukocytes have the capacity to supply proteolytic enzymes capable of generating kinin activity from a plasma protein substrate, kininogen, under diverse reaction conditions (1-3). Experiments, initially directed toward the mechanism of neutrophil-dependent kinin generation, have uncovered a different system which is controlled by ec-l-antitrypsin. Incubation of crude neutroph...

While polymorphonuclear leukocytes appear to play a major role in many of the biologic effects of bacterial endotoxin,1' the mechanism by which endotoxin interacts with these cells is not clear. Recent studies from this laboratory showed that phagocytosis of several different types of particles inhibited neutrophil migration in microhematocrit tubes.8 This inhibition was due to both decreased m...