Since Coley and Stewart (1945) recorded two cases of sarcomatous change in polyostotic fibrous dysplasia, there have been a further twelve reported cases ofmalignant change occurring in patients with fibrous dysplasia (Table I). Eight ofthese occurred in patients with polyostotic fibrous dysplasia and, of these, three were in patients with Albright’s syndrome. Of the other six patients, in five...

The lesions of fibrous dysplasia usually stabilize after adolescence, and the surgical treatment of adult patient remains the mainstay. However, the surgical treatment alone may be not enough for patient with polyostotic fibrous dysplasia. We present the case of a surgically treated 36-year-old man with a diagnosis of progressive polyostotic fibrous dysplasia in the craniomaxillofacial region. ...

BACKGROUND Fibrous dysplasia (FD) is a benign fibro-osseous lesion related to an abnormal bone development and replacement by fibrous tissue. FD has three clinical patterns namely monostotic, polyostotic, and the McCune-Albright syndrome (MAS). MAS is a rare genetic disorder (about 3% of all FD's) that comprises a triad of polyostotic FD, café-au-lait skin macules, and precocious puberty. MAS c...

We report the case of a 12-year-old boy with polyostotic fibrous dysplasia of the upper femur in whom a massive customised polyethylene prosthesis functioned successfully for more than fifty years.

Fibrous dysplasia is a benign intramedullary lesion characterized by an excessive proliferation of cellular fibrous tissue intermixed with irregular trabeculae. It involves any of the bones presenting as monostotic, polyostotic, or panostotic lesion. It is caused by mutation in the GNAS1 gene (20q13.2, encoding a G-protein) resulting in inhibition of intrinsic GTPase activity of Gs alpha protei...

Paget's disease of bone is a common metabolic bone disease in most of the European countries. The disease has distinct geographical distribution being rare in Asia. We report Paget's disease in a 70 years old Pakistani male who presented with history of pain in right leg with difficulty in walking for the last 5 months. Plain X-ray raised suspicion of Paget's disease of bone. Technetium-99m MDP...