Chemotherapeutic agents may damage gastrointestinal epi thelium and thereby impair the mucosal barrier to bacteria and their products. In order to obtain an objective measurement of gastrointestinal permeability to large molecules, we measured urinary excretion of [14C]polyvinylpyrrolidone administered p.o. (mean molecular weight 11,000) and tobramycin (molecular weight 467) in ten patients rec...

Our aim in this work is the synthesis and study optical and structural properties of gold nanoparticles.Gold (III) chloride trihydratewas taken as metal precursor, ascorbic acid at the presence of an appropriate amount of NaOH as reducing agent and polyvinylpyrrolidonek-30 (PVP K-30) as a stabilizing and capping agent. The reaction was performed in high-speed stirring rate at room temperature.S...

In this research, CaO (calcium oxide) nanoparticles were synthesized by Co-Precipitation method in the absence and presence of Polyvinylpyrrolidone (PVP) via using calcium (II) nitrate. The Polyvinylpyrrolidone (PVP) was used as a capping agent to control the agglomeration of the nanoparticles. The synthesized samples were characterized via SEM, XRD and FTIR techniques. The average sizes of nan...

Chemotherapeutic agents may damage gastrointestinal epithelium and thereby impair the mucosal barrier to bacteria and their products. In order to obtain an objective measurement of gastrointestinal permeability to large molecules, we measured urinary excretion of [14C]polyvinylpyrrolidone administered p.o. (mean molecular weight 11,000) and tobramycin (molecular weight 467) in ten patients rece...

Objective . To optimize the composition of polymer coatings based on assessment duration antibacterial resistance in infected wounds laboratory animals. Materials and methods Woven vascular prostheses consisting fibrous-porous polypropylene one three types a polyvinyl-chitosan complex with addition biologically active substances were used study. All samples impregnated 1% vancomycin for 30 minu...

Complexation of celecoxib with ß-cyclodextrin and hydroxypropyl-ß-cyclodextrin in the presence and absence of polyvinylpyrrolidone and the effect of polyvinylpyrrolidone on the solubilizing efficiency of cyclodextrins and on the dissolution rate of celecoxib from the cyclodextrin complexes were investigated. The phase solubility studies indicated the formation of celecoxib-ß-cyclodextrin and ce...

Freeze-drying (FD) and solvent evaporation (SE) were used to prepare solid dispersions (SDs) of meloxicam (MX) in polyvinylpyrrolidone K-30 (PVP). The SDs were prepared at different ratios, namely 1:1, 1:3, and 1:5 MX:PVP weight ratio. Differential scanning calorimetry (DSC), infrared absorption spectroscopy (IR), and x-ray powder diffractometry (XPD) were utilized to characterize the physicoch...

Pelletized dosage forms can be prepared by different methods which, in general, are time consuming and labor intensive. The current study was carried out to investigate the feasibility of preparing the spherical pellets of omeprazole by sieving-spheronization. An optimized formulation was also prepared by extrusion-spheronization process to compare the physical parameters between these two meth...