A procedure has been developed for the assay of urinary porphyrins. Total porphyrins are extracted from acidified urine into n-butanol. The fluorescence of this solution under ultraviolet illumination gives a preliminary indication of abnormal levels of porphyrins. They are then separated and identified by thin-layer chromatography. Uroporphyrin and coproporphyrin can be qualitatively estimated...

The synthesis and photophysical properties of cyano and ethynyl substituted carbazole-based porphyrins were investigated. The introduction of ethynyl groups induced red shifts, while that of cyano groups induced blue shifts of their absorption bands, which was supported by MO calculations. Ethylenedioxy-appended porphyrins were also prepared via a coupling reaction. The conjugated and electroni...

The aim of this study was to complete research on the porphyrogenic effect of hexabrombenzene (HBB) and tetrabromobisphenol-A (TBBP-A). Experiments were performed on female Wistar rats. The examined compounds were administered in sunflower oil intragastrically in 3 doses. The determination of porphyrins in tissues was carried out by means of high-performance liquid chromatography. Repeated HBB ...

The second-generation quinolone ofloxacin interferes with the screening test of porphyrins. We observed a 20-fold increase in the porphyrin concentration measured in urine of an ofloxacin-treated patient, compared with drug-free normal urine. Two other fluorinated 4-quinolones tested, norfloxacin and ciprofloxacin, had a less marked effect (a twofold increase), whereas the first-generation quin...

Water-soluble porphyrins can be phase transferred by the hyperbranched multiarm copolymer PEI-PZLys; good catalytic activities and recyclabilities were observed for oxidation catalyzed by the encapsulated porphyrins.

We synthesized two water-soluble porphyrins appending platinum(II) complexes [alpha,beta-(4a) and alpha,alpha-(4b) 5,15-bis(2-trans-[PtCl(NH3)2]N-2-aminoethylaminocarbonylphenyl) 2,3,7,8,12,13,17,18-octamethylporphyrin] and studied their reactions with a variety of nucleic acids [disodium adenosine-5'-monophosphate (AMP), disodium guanosine-5'-monophosphate (GMP), disodium thymidine-5'-monophos...

Herein we report the synthesis of unsymmetrical meso-aryl substituted porphyrins, using NaY zeolite as an inorganic acid catalyst. A comparative study between this method and the several synthetic strategies available in the literature was carried out. Our method presented a better, more cost-efficient rationale and displayed a significantly lower environmental impact. Furthermore, it was possi...

Porphyrins and N-heterocyclic carbenes (NHCs) are both relevant ligands in the fields of coordination organometallic chemistry. Despite evident structural differences, porphyrins NHCs have a lot common such as their ability to form strong metal-ligand bonds use catalysis, materials science biomedicine. During last decade, several molecular systems combining NHC were reported literature. The pre...

Porophyrins and their metal derivatives are strong DNA binders with association constant of  to  . Some of these compounds have been used for the radiations sensitization therapy of cancer and are targeted to interact with cellular DNA. Binding of porphyrins to DNA changes the expectral and other physic chemical characteristic of porphyrins, The mode of binding can be extracted from inspection ...

A third crystalline modification of dodecaphenylporphyrin is described in which the pyrrole ni­ trogen atoms are hydrogen-bonded to two etha­ nol molecules. This is the first crystallographic proof for the accessibility of nitrogen atoms in saddle-distorted free base porphyrins for hy­ drogen bonding. No such coordination is possible in either planar or ruffled porphyrins. Thus, the possibility...