OBJECTIVE To evaluate the role of radiotherapy (RT) in overall survival (OS) and disease-free survival in postmastectomy breast cancer patients with tumor size <5 cm, with 1-3 involved axillary lymph nodes (T1-2N1). PATIENTS AND METHODS We conducted a retrospective study of 89 postmastectomy patients with T1-2N1 disease between 2005 and 2015 at the Radiation Oncology Clinic of Kayseri Trainin...

Postmastectomy locoregional radiation therapy markedly reduces the risk of locoregional recurrence. Several randomized trials, including two recently updated studies with 10- to 15-year follow-up, demonstrate an improvement in overall survival with radiation therapy. This improvement is seen in patients with one to three positive axillary lymph nodes, as well those with four positive nodes. The...

INTRODUCTION: Silicone breast implants have been used for decades for cosmetic breast augmentation or reconstruction after mastectomy1. In selected cases, postmastectomy adjuvant radiotherapy is given with the breast implants in situ. Previous clinical studies showed that adjuvant radiotherapy may lead to several complications such as capsular contracture, infection and removal of the implant.2...

INTRODUCTION: Silicone breast implants have been used for decades for cosmetic breast augmentation or reconstruction after mastectomy1. In selected cases, postmastectomy adjuvant radiotherapy is given with the breast implants in situ. Previous clinical studies showed that adjuvant radiotherapy may lead to several complications such as capsular contracture, infection and removal of the implant.2...

PURPOSE Cyclooxygenase-2 (COX-2) expression has been shown to be associated with radiation resistance, which theoretically could be overcome with the use of COX-2 inhibitors. The purpose of this study was to assess the prognostic significance and clinical correlations of COX-2 expression (COX) in a cohort of patients treated with radiation for postmastectomy chest wall relapse. EXPERIMENTAL D...

BACKGROUND Postmastectomy breast reconstruction is widely used in breast cancer patients for its aesthetic effect. Although several studies have casted suspicion upon the oncological safety of immediate breast reconstruction after mastectomy, the potential impact of different reconstruction methods on patient survival remains unclear. PATIENTS AND METHODS We identified 35,126 female patients ...

Objective: Postmastectomy radiation therapy is a well-established risk factor for complications after breast reconstruction. Even if the surgeon has a suspicion that radiation therapy may be needed, it may be beneficial to place tissue expanders during the mastectomy procedure as a temporizing measure, complete radiation therapy, and then reconstruct the breast with a latissimus flap. The purpo...