OBJECTIVE Slowing of gastric emptying by hyperglycemia, a physiological response to minimize postprandial hyperglycemia, may be impaired in patients with type 1 diabetes. The causes and consequences on glucose homeostasis are unknown. RESEARCH DESIGN AND METHODS Consequences of euglycemia- and hyperglycemia-induced changes in gastric emptying on postprandial glucose fluxes and excursions were...

The studies devoted to contributions of postprandial (PPG) and fasting/ basal glucose to overall hyperglycemia remain limited to non–insulin-using diabetic patients, and most reports indicate that PPGmakes the highest contribution in patients with satisfactory control (1). Recently, Riddle et al. (2) have challenged this concept and extended the analysis to type 2 diabetic patients treated with...

The aim of this article is to evaluate the pros and cons of a specific impact of postprandial hyperglycemia and glycemic variability on the--mainly cardiovascular (CV)--complications of diabetes, above and beyond the average blood glucose (BG) as measured by HbA(1c) or fasting plasma glucose (FPG). The strongest arguments in favor of this hypothesis come from impressive pathophysiological studi...

This article reviews the role of fasting and postprandial glycemia to the overall glycemic control of patients with type 2 diabetes and glucose intolerance, as well as their causal relationship upon micro and macrovascular complications. Recent studies have suggested that a third component of the glucose triad, the postprandial glucose excursions, might have a role in the overall glycemic load ...

BACKGROUND Postprandial hyperglycemia is believed to affect vascular endothelial function. The aim of our study was to compare the effects of acarbose and nateglinide on postprandial endothelial dysfunction. METHODS We recruited a total of 30 patients with newly diagnosed type 2 diabetes (19 men and 11 women, age 67.8 +/- 7.3 years). Patients were randomly assigned to 3 groups receiving eithe...

OBJECTIVE The exact contributions of postprandial and fasting glucose increments to overall hyperglycemia remain controversial. The discrepancies between the data published previously might be caused by the interference of several factors. To test the effect of overall glycemic control itself, we analyzed the diurnal glycemic profiles of type 2 diabetic patients investigated at different levels...

ABSTRACT We examined whether peripheral leukocytes of mice derived from in vitro αMEM-cultured embryos and exhibiting type 2 diabetes had higher expression inflammatory-related genes associated with the development atherosclerosis. Also, we impact a barley diet on inflammatory gene expression. Adult were produced by embryo transfer, after culturing two-cell for 48 h either α minimal essential m...

We thank Monnier (1) for his interest in and comments on our article (2). We believe his original work on the relationships between fasting and postprandial hyperglycemia has opened discussion on various important questions, both physiological and clinical (3). In our present analysis, we aimed to extend this work by addressing two of the clinical questions in a larger population than has previ...

BACKGROUND Postprandial hyperglycemia is an early defect of type 2 diabetes and one of primary anti-diabetic targets. Treatment of postprandial hyperglycemia can be achieved by inhibiting intestinal α-glucosidase, the key enzyme for oligosaccharide digestion and further glucose absorption. Grape pomace is winemaking byproduct rich in bioactive food compounds such as phenolic antioxidants. This ...