BACKGROUND Neoadjuvant chemotherapy followed by surgery is the standard of care for UK patients with locally advanced resectable oesophageal carcinoma (OeC). However, not all patients benefit from multimodal treatment and there is a clinical need for biomarkers which can identify chemotherapy responders. This study investigated whether the proportion of tumour cells per tumour area (PoT) measur...

Pot-in-pot reactions are designed such that two reaction media (solvents, catalysts and reagents) are isolated from each other by a polymeric membrane similar to matryoshka dolls (Russian nesting dolls). The first reaction is allowed to progress to completion before triggering the second reaction in which all necessary solvents, reactants, or catalysts are placed except for the starting reagent...

Batch cultures of mouse LS cells were grown in suspension at controlled dissolved oxygen partial pressures (pOt). At low pOt (i-6 mmHg) the growth and respiration rates and the final cell population were all limited. At high pOt (320 mmHg), cell division was inhibited after an initial doubling of the cell number. At intermediate values of pOt, the growth rate was constant but the final cell pop...

Effect of cooking, fermentation, dehulling and the use of utensils on flavonoids (quercitin and pelargonidin) - antioxidants present in pearl millet (Pennisetum typhoideum) rabadi, along with proximate composition and sensory acceptability of the product were studied. Study revealed an increased ash and flavonoids and reduced crude fibre after cooking in all samples, while fermentation enhanced...

BACKGROUND & OBJECTIVES Sputum acid-fast bacilli (AFB) microscopy services are not available in all health facilities. Alternative procedures are needed to transport sputum samples to the diagnostic centres for detection of AFB. The objective of the present study was to evaluate sputum smears made by pot-method with the direct smears made immediately after sputum collection by Ziehl-Neelsen (ZN...

My girlfriend tells me she uses marijuana to calm herself if she is having a stressful day. She has been doing this for many years. She says smoking pot is like self-medicating ? it is better than using anti-depressants. She also claims smoking pot helps with depression because of how it helps produce serotonin in the body. What is serotonin and how does it help depression? Does smoking pot rea...

My girlfriend tells me she uses marijuana to calm herself if she is having a stressful day. She has been doing this for many years. She says smoking pot is like self-medicating ? it is better than using anti-depressants. She also claims smoking pot helps with depression because of how it helps produce serotonin in the body. What is serotonin and how does it help depression? Does smoking pot rea...

My girlfriend tells me she uses marijuana to calm herself if she is having a stressful day. She has been doing this for many years. She says smoking pot is like self-medicating ? it is better than using anti-depressants. She also claims smoking pot helps with depression because of how it helps produce serotonin in the body. What is serotonin and how does it help depression? Does smoking pot rea...

My girlfriend tells me she uses marijuana to calm herself if she is having a stressful day. She has been doing this for many years. She says smoking pot is like self-medicating ? it is better than using anti-depressants. She also claims smoking pot helps with depression because of how it helps produce serotonin in the body. What is serotonin and how does it help depression? Does smoking pot rea...

My girlfriend tells me she uses marijuana to calm herself if she is having a stressful day. She has been doing this for many years. She says smoking pot is like self-medicating ? it is better than using anti-depressants. She also claims smoking pot helps with depression because of how it helps produce serotonin in the body. What is serotonin and how does it help depression? Does smoking pot rea...