نتایج جستجو برای: ppar

تعداد نتایج: 7946  

2003
Christopher H. Hurst David J. Waxman

Phthalate esters are widely used as plasticizers in the manufacture of products made of polyvinyl chloride. Mono-(2-ethylhexyl)phthalate (MEHP) induces rodent hepatocarcinogenesis by a mechanism that involves activation of the nuclear transcription factor peroxisome proliferator-activated receptor-alpha (PPAR ). MEHP also activates PPAR-gamma (PPAR ), which contributes to adipocyte differentiat...

Journal: :journal of research in medical sciences 0
parizad taraghijou students' research committee,department of nutrition, tabriz university of medical science, tabriz, iran abdolrasoul safaeiyan departments of vital statistics and epidemiology, tabriz university of medical science, tabriz, iran majid mobasseri medicine, endocrinology and metabolism section, imam reza hospital , tabriz university of medical science, tabriz, iran alireza ostadrahimi nutrition research center, tabriz university of medical science, tabriz, iran

background : peroxisome proliferator-activated receptor gamma (ppar γ) is a transcription factor, which is abundantly expressed in adipose tissue and has a direct link to adiposity. it seems that long-chain polyunsaturated fatty acids (lc-pufas) can regulate ppar γ expression. the purpose of this study was to investigate the effects of n-3lc pufa supplementation on plasma levels of ppar γ and t...

2005

The peroxisome proliferator-activated receptors (PPAR) are nuclear receptors that regulate gene expression in response to ligand binding. Three PPAR receptor subtypes, namely gamma, alpha and delta (beta), have been identified. The development of PPAR agonist pharmaceuticals for the treatment of type 2 diabetes, dyslipidemia, and obesity is currently an area of great interest. The FDA has recei...

2009
Ferhana Y. Ali Matthew G. Hall Béatrice Desvergne Timothy D. Warner Jane A. Mitchell

Objectives—Peroxisome proliferator-activated receptor / (PPAR / ) is a nuclear receptor found in platelets. PPAR / agonists acutely inhibit platelet function within a few minutes of addition. As platelets are anucleated, the effects of PPAR / agonists on platelets must be nongenomic. Currently, the particular role of PPAR / receptors and their intracellular signaling pathways in platelets are n...

Journal: :Journal of the National Cancer Institute 2014
Xiangsheng Zuo Min Xu Jiang Yu Yuanqing Wu Micheline J Moussalli Ganiraju C Manyam Sun Il Lee Shoudan Liang Mihai Gagea Jeffrey S Morris Russell R Broaddus Imad Shureiqi

BACKGROUND The nuclear receptor peroxisome proliferator-activated receptor-δ/β (PPAR-d) is upregulated in human colorectal cancers, but its role in colonic tumorigenesis remains controversial. METHODS We generated a novel mouse model of intestinally targeted PPAR-d overexpression to simulate PPAR-d upregulation in human colon carcinogenesis. Colon-specific PPAR-d overexpression was confirmed ...

2014
Abhita Malaviya Paul W Sylvester

Previous findings showed that the anticancer effects of combined γ -tocotrienol and peroxisome proliferator activated receptor γ (PPAR γ ) antagonist treatment caused a large reduction in PPAR γ expression. However, other studies suggest that the antiproliferative effects of γ -tocotrienol and/or PPAR γ antagonists are mediated, at least in part, through PPAR γ -independent mechanism(s). Studie...

2001
Songtao Yu Wen-Qing Cao P. Kashireddy Kirstin Meyer Yuzhi Jia Douglas E. Hughes Yongjun Tan Jianchi Feng Anjana V. Yeldandi M. Sambasiva Rao Robert H. Costa Frank J. Gonzalez Janardan K. Reddy

Peroxisome proliferators, which function as peroxisome proliferator-activated receptor (PPAR ) agonists, induce peroxisomal, microsomal, and mitochondrial fatty acid oxidation enzymes, in conjunction with peroxisome proliferation, in liver cells. Sustained activation of PPAR leads to the development of liver tumors in rats and mice. The assertion that synthetic PPAR ligands pose negligible carc...

2005
Jie Lu Kazuhiro Imamura Sachiyo Nomura Ken-ichi Mafune Atsushi Nakajima Takashi Kadowaki Naoto Kubota Yasuo Terauchi Genichiro Ishii Atsushi Ochiai Hiroyasu Esumi Michio Kaminishi

Peroxisome proliferator–activated receptor ; (PPAR;) is known to be expressed in several cancers, and the treatment of these cancer cells with PPAR; ligands often induces cell differentiation and apoptosis. Recently, the chemopreventive potential of PPAR; ligands on colon carcinogenesis was reported, although the effect of PPAR; on colon carcinogenesis and the mechanism of the effect remain con...

2002
Levy Kopelovich Judith R. Fay Robert I. Glazer James A. Crowell

Peroxisome proliferator-activated receptors (PPARs), members of the superfamily of nuclear steroid hormone receptors, have traditionally been studied for their role in lipid, glucose, and energy homeostasis. Recent evidence suggests that pharmacological activation of PPAR and PPAR , and inhibition of PPAR , may prevent cancer. PPAR agonists induce differentiation, inhibit the growth of establis...

Journal: :Life Sciences 2021

Kaempferide (Ka, 3,5,7-trihydroxy-4?-methoxyflavone), an active ingredient of Tagetes erecta L., has been demonstrated to possess many pharmacological effects, including antioxidant, anti-inflammation, anticancer and antihypertension in previous study. However, there is no evidence Ka on metabolic disorder former studies. This study investigated the effects glycolipid metabolism explored underl...

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