Allergen immunotherapy (AIT) is a guidelines-approved, disease-modifying treatment option for respiratory allergies, including allergic rhinitis (AR) induced by pollen. The various AIT regimens employed to date in pollen-induced AR can be classified as continuous (i.e. year-round) or discontinuous (i.e. pre-seasonal alone, co-seasonal alone or pre- and co-seasonal). Pre-and co-seasonal regimens...

A study that combines microneedles (MNs) and sonophoresis pre-treatment was explored to determine their combined effects on percutaneous delivery of lidocaine from a polymeric hydrogel formulation. Varying ratios of carboxymethylcellulose and gelatine (NaCMC/gel ranges 1:1.60-1:2.66) loaded with lidocaine were prepared and characterized for zeta potential and particle size. Additionally, variat...

Variable splitting schemes for the function space TV-model in its primal and pre-dual formulations are considered. In the primal splitting formulation, while existence of a solution cannot be guaranteed, it is shown that quasi-minimizers of the penalized problem are asymptotically related to the solution of the original TV-model. On the other hand, for the pre-dual formulation a family of param...

In this work, a general formulation for fault detection in stochastic continuoustime dynamical systems is presented. This formulation is based on the definition of a pre-Hilbert space so that orthogonal projection techniques, based on the statistics of the involved stochastic processes can be applied. The general setting gathers different existing schemes within a unifying framework.

An algorithm to compute classical trajectories using boundary value formulation is presented and discussed. It is based on an optimization of a functional of the complete trajectory. This functional can be the usual classical action, and is approximated by discrete and sequential sets of coordinates. In contrast to initial value formulation, the pre-specified end points of the trajectories are ...

Nolde and Morari [10] study a steel manufacturing scheduling problem where the tasks must be scheduled such that electricity consumption matches to a pre-specified periodic energy chart. They propose a continuous time integer linear programming formulation to solve the problem. In this note, we present an alternative continuous time formulation that improves significantly the computation time.

During unscripted speech, speakers coordinate the formulation of pre-linguistic messages with the linguistic processes that implement those messages into speech. We examine the process of constructing a contextually appropriate message and interfacing that message with utterance planning in English (the small butterfly) and Spanish (la mariposa pequeña) during an unscripted, interactive task. T...

One of the most significant issues in pharmaceutical industries, prior to commercializationof a pharmaceutical preparation is the “preformulation” stage. However, far too attention hasbeen paid to verification of the software assisted statistical designs in preformulation studies.The main aim of this study was to report a step by step preformulation approach for a semisolidpreparation based on ...