Background: Prediabetes is a metabolic condition which is characterized by the presence of higher levels of blood glucose. It can be treated by lowering high blood glucose level and maintaining the healthy lifestyle habits, healthy meal plan and regular exercise. The aim of this study was to evaluate the prevalence of prediabetes and to identify the risk factors involved in its progression. Ma...

BACKGROUND The incidence of diabetes is increasing. But the impact of diabetes and prediabetes on survival of patients with nasopharyngeal carcinoma (NPC) has received little evaluation. METHODS In a cohort of 5,860 patients, we compared the disease specific survival (DSS), locoregional relapse-free survival (LRFS) and distant metastasis-free survival (DMFS) of patients with diabetes, prediab...

Dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. The aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). In this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

There is robust evidence that sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of adverse cardiovascular and kidney outcomes. The DAPA-CKD trial (NCT03036150) demonstrated a significant reduction in participants with chronic disease (CKD), without type diabetes, treated dapagliflozin 10 mg once daily compared placebo, as an adjunct to standard care. In this prespecified analysi...

conclusions because of increasing prevalence of prediabetes at earlier age, it seems necessary to reconsider the screening age in urban areas and perform the screening in all adults at younger ages. results the prevalence of diabetes was 7.04% (4.52% women, 2.52% men) and the prevalence of prediabetes was 8.58% (5.59% women, 2.98% men). thehighest prevalence of diabetes and prediabetes were obs...

Animal models are very common in diabetes research when rodents are mostly used in this regard. Although a number of animal models of type 1 and type 2 diabetes (T2D) are developed in last few decades, the numbers of animal models of prediabetes and insulin resistance are very scanty. Due to the rapidly changing pathogenesis of the disease and preventive study, the popularity of the prediabetic...

CONTEXT The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies. OBJECTIVE This study aimed to evaluate whether the E23K variant could predict glycaemic progression in a Southern Chinese population. METHODS/PRINCIPAL FINDINGS We performed a long-term prospective study on 1912 ...

It is estimated that 79 million people in the United States (35% of adults ≥ 20 years of age and 50% of adults ≥ 65 years of age) have mild degrees of hyperglycemia and are thereby at risk for developing type 2 diabetes.1 Scientific jargon such as “impaired glucose tolerance” (IGT), “impaired fasting glucose” (IFG), and “elevated A1C” may be too technical or cumbersome to use with most patients...

OBJECTIVE The association ns between prediabetes and androgens have been rarely reported, especially in Chinese men. We aimed to investigate whether androgens were associated with the prevalence of prediabetes diagnosed with new American Diabetes Association criteria in Chinese men and then to assess which androgen value was the most relevant factor. METHODS A total of 2654 men (52.6±13.4 yea...

INTRODUCTION Estimates indicate that 86 million people in the United States fit the clinical definition of prediabetes, which contributes to the epidemic of nearly 2 million new diagnoses of type 2 diabetes mellitus each year. Effort has focused on preventing prediabetes from progressing to clinical diabetes. We investigated the sociodemographic, behavioral, and health factors in people diagnos...