introduction: the purpose of this study was to cultivate bone marrow cells from two different mouse strains (nmri and balb/c) and to examine them in terms of expression of ten surface antigens from primary culture to passage 3. material and methods: 6-8 weeks old either nmri or balb/c mice were sacrificed and their bone marrows were harvested and cultivated .two weeks after culture initiation, ...

Introduction Dendritic cells (DCs) are bone marrow-derived cells, which migrate to lymphoid and non-lymphoid organs via blood. Liver DCs are believed to play an important role in the regulation of hepatic allograft acceptance. However, because of inherent difficulties in isolating adequate numbers of DCs from liver, limited information is available on the phenotype and functions of liver DCs. ...

Abstract Metastases are the primary cause of cancer mortality, and different sites metastasis associated with prognostic outcomes. In particular, liver metastases poor overall survival increased disease progression. It is known that suppress systemic antitumor immunity to limit immunotherapy efficacy on tumors through hepatic siphoning deletion CD8 +T cells, induction T regulatory depletion den...

background: this study was carried out to observe the radioprotective effects of rosemarinus officinalis leaves extract (roe) against radiation-induced histopathological alterations in liver of mice. materials and methods: adult swiss albino mice were exposed to 6 gy gamma radiation in the presence (experimental) or absence (control) of roe to study the qualitative and quantitative alterations ...

Background: This study was carried out to observe the radioprotective effects of Rosemarinus officinalis leaves extract (ROE) against radiation-induced histopathological alterations in liver of mice. Materials and Methods: Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of ROE to study the qualitative and quantitative alt...

Background: Protection of hematopoietic system has become a primary goal in the development of novel medical countermeasures against ionization radiation and radiotherapy. This study was to explore the role of rapamycin in normal tissues against radiation. Materials and Methods: Mice were pretreated with rapamycin by i.p. every other day for five times before 5 Gy or 8.5 Gy γ-ray whole bo...

background nonalcoholic fatty liver disease (nafld) is the most common cause of chronic liver disease in western world. however, nafld shows an increasing trend in china every year, which has attracted the attention of national health authorities. the previous studies have shown that nafld caused severe gastrointestinal motor disorders, but little is known about the interstitial cells of cajal ...

many investigators have used xenogeneic, especially murine stromal cells and fetal calf serum to maintain and expand human stem cells. the proliferation and expansion of human hematopoietic stem cells in ex vivo culture were examined with the goal of generating a suitable protocol for expanding hematopoietic stem cells for patient transplantation. using primary fetal liver cells, we established...

This study aimed to evaluate the in-vitro and in-vivo biological activities of newly synthesized nanochelating based silver nanoparticles (AgNPs) in mouse model. Nanochelating technology was used to design and synthesize the AgNPs. The animals studies were including the lethal dose (LD50) determination by the intraperitoneal administration in mice, and determination of liver e...

This study aimed to evaluate the in-vitro and in-vivo biological activities of newly synthesized nanochelating based silver nanoparticles (AgNPs) in mouse model. Nanochelating technology was used to design and synthesize the AgNPs. The animals studies were including the lethal dose (LD50) determination by the intraperitoneal administration in mice, and determination of liver e...