The effects of intravenous magnesium on exercise-induced angina were examined in 15 patients with variant angina and in 13 patients with stable effort angina and were compared with those of placebo. Symptom-limited bicycle exercise and thallium-201 myocardial scintigraphy were performed after intravenous administration of 0.27 mmol/kg body weight of magnesium sulfate and after placebo on differ...

Classical angina pectoris is characterized by recurrent attacks of retrosternal pain brought on by effort and emotion and relieved by rest and the administration of nitroglycerin. It is well known that this classical syndrome has many variations and modifications. In 1959, and again in 1960, Prinzmetal and his colleagues described what they called a "variant form of angina pectoris." According ...

To define more completely regional coronary hemodynamic changes that occur during spontaneous angina pectoris in patients with variant angina, we measured coronary sinus and great cardiac vein blood flow (CSF and GCVF) and aortic and left ventricular pressures before and during spontaneous angina in six patients with variant angina. During spontaneous angina, ECGs in four patients showed eviden...

BACKGROUND Coronary artery spasm induces activation of the coagulation system. Turnover and maintenance of thrombus depend not only on formation but also on lysis. The relation between coronary spasm and fibrinolytic system has not been elucidated. OBJECTIVE To examine whether there is impairment of or a circadian variation in fibrinolytic activity in patients with variant angina. METHODS P...

Variant angina pectoris (VAP) is a form of angina pectoris that shows transient ST-segment elevation on electrocardio-gram during an attack of chest pain and is caused by coronary artery spasm. Although the pathogenesis of coronary artery spasm has not been fully elucidated, endothelial dysfunction and enhanced vascular smooth muscle contractility play major roles in the pathogenesis of coronar...

We consider two-dimensional turbulence driven by a steady prescribed sinusoidal body force working at an average rate epsilon. Energy dissipation is due mainly to drag, which damps all wave number at a rate micro. Simulations at statistical equilibrium reveal a scaling regime in which epsilon proportional, variant micro;{1/3}, with no significant dependence of epsilon on hyperviscosity, domain ...

Mechanisms underlying coronary spasm are still poorly understood. The aim of the study was to assess the hypothesis that fluctuations in the development of coronary spasm might reflect inputs from the adjacent esophageal system. We enrolled patients admitted to the coronary care unit for episodes of nocturnal angina. Seven patients with variant angina and five with coronary artery disease (CAD)...

Plasma levels of fibrinopeptide A (FPA), beta-thromboglobulin (BTG), and platelet factor 4 (PF4) were examined on venous plasma samples taken every 4 hours for 24 hours in 20 patients with variant angina and 20 patients with stable exertional angina together with 24-hour Holter recordings. The mean plasma FPA levels (ng/ml) at 2:00 PM, 6:00 PM, 10:00 PM, 2:00 AM, 6:00 AM, and 10:00 AM were 4.6 ...