PSA is a 33-KDa serine protease that is produced predominantly by prostate epithelium. However, it has been shown that about 30-40% of female breast tumors produce PSA and its production is associated with the presence of estrogen and progesterone receptors. We have now developed a new tissue culture system to study PSA production in breast cancer and its association with prognostic factors...

objective(s): neuroprotective effects of female gonadal steroids are mediated through several pathways involving multiple peptides and receptors after traumatic brain injury (tbi). two of these peptides are including the regulatory peptides neuromedin u (nmu) and neuromedin s (nms), and their common receptor neuromedin u2 receptor (nmur2). this study investigates the effects of physiological do...

psa is a 33-kda serine protease that is produced predominantly by prostate epithelium. however, it has been shown that about 30-40% of female breast tumors produce psa and its production is associated with the presence of estrogen and progesterone receptors. we have now developed a new tissue culture system to study psa production in breast cancer and its association with prognostic factors suc...

the cyclical changes in the gonadotropins stimulate ovarian follicular development either to the ovulatory stage or to undergo atresia. one such intrafollicular factor may be inter-cellular communication via gap junctions. we have examined the effects of two agents (retinoids and alkanols), known to disrupt or uncouple gap junction, on fsh-stimulated lh receptor induction and progestrone synthe...

background and objectives: breast cancer is the most common malignancy among women in the world. the aim of this study was to assess estrogen receptor (er), progesterone receptor (pr) and her-2/neu of infiltrating ductal carcinoma (idc) with tumor size, histologic grade, lymph node metastasis and age. methods: this study was carried out on 300 tissue blocks ofpatients with idc who underwent mas...

A possible involvement of gender-dependent factors has been postulated in development of human non-small-cell lung cancers (NSCLC), but its details remain unclear. In this study, we examined biological significance of progesterone receptor in NSCLCs. Progesterone receptor immunoreactivity was detected in 106 of 228 NSCLCs (46.5%). Progesterone receptor-positive NSCLC was frequently detected in ...

Background: Breast cancer is the most commonly diagnosed and the leading cause of cancer death among females worldwide. The rate of breast cancer incidence among Iranian women is 17% of all cancers, it has been ranked first in Iran. This study aimed to investigate the factors affecting axillary lymph node involvement in female patients with breast cancer. Methods: A cross-sectional study was c...

Breast cancer is a complicated disease that it is accompanied by different symptoms. Diagnosis of this disease is performed by various techniques. Using Radiopharmaceuticals is a new method to diagnose the said tumors. [18F]-FPTT is one of these nuclear medicines for detection of breast cancer. It seems that the binding of the title radiopharmaceutical to the progesterone receptor is...