Adapting tools to a particular domain is expensive, and the adaptation is often not very deep. To address this challenge, Generic Tools, Specific Languages shifts the focus from building and adapting tools (windows, buttons, algorithms) to building and adapting languages to a domain. The thesis applies the approach to embedded software development: mbeddr is an extensible set of integrated lang...

It is shown in detail how recent advances in multiple-output and projectional quantile regression open the door to exact computation of many inferential statistics based on projection pursuit. This is also illustrated on a few examples including new regression generalizations of multivariate skewness, kurtosis and projection depth. Note: The following files were submitted by the author for peer...

Domain-specific languages (DSLs) are of increasing importance in scientific high-performance computing to reduce development costs, raise the level of abstraction and, thus, ease scientific programming. However, designing and implementing DSLs is not an easy task, as it requires knowledge of the application domain and experience in language engineering and compilers. Consequently, many DSLs fol...

Cervical spine radiographs are crowded with superimposed bony and soft-tissue structures that make interpretation difficu lt. In addition, there are many anatomic and projectional variants that have been described [1-6] . Knowledge of them is essential to distinguish the normal from the pathologic. We illustrate another pseudolesion , the C2 "target, " and provide a radiologic description and a...

To be able to build effective DSLs, these DSLs must not just use language concepts that are aligned with their respective domain, but also use notations that correspond closely to established domain notations – and those are often not purely textual or graphical. The underlying language workbench must support these notations, and combining different notations in a single editor must be supporte...

Though rare, anomalous coronary artery disease is a well-known cause of myocardial ischemia and sudden death among children and young adults. The projectional nature of conventional x-ray angiography often leads to difficulty in the definition of anomalous vessels. Studies have now documented the high accuracy of coronary magnetic resonance angiography (MRA) for the noninvasive detection and de...

Product line engineering deals with managing and implementing the variability among a set of related products. We distinguish between two kinds of variability: configuration and customization. Customization variability can be described using programming language code or creative construction DSLs, whereas configuration variability is described using configuration based approaches, such as featu...

oninvasive imaging of the coronary arteries is fraught with reat difficulties: Most obviously, coronary vessels have mall dimensions, which requires high spatial resolution. lso, they are subjected to rapid motion because of cardiac ontraction. Sufficient temporal resolution is thus necessary o avoid artifacts. Finally, in invasive angiography, the oronary artery lumen can be selectively filled...