OBJECTIVES (a) To report on the basic parameters of retinal blood flow in a population of diabetic patients with and without retinopathy and non-diabetic controls; (b) to formulate a haemodynamic model for the pathogenesis of diabetic retinopathy from this and other studies. DESIGN Laser-Doppler velocimetry and computerised image analysis to determine retinal blood flow in a large cross secti...

INTRODUCTION Diabetes mellitus (DM) is associated with serious complications including macro- and microvascular problems such as diabetic retinopathy. Coronary involvement in diabetic patients is believed to be a consequence of microvascular complications. However, the available data are inconclusive and scarce. This study aimed to evaluate the probable association between diabetic retinopathy ...

BACKGROUND Population-based data on the prevalence of diabetic retinopathy in Pakistan are lacking. We determined the prevalence of diabetic retinopathy among individuals screened positive for diabetes in five community-based eye camps in northern Karachi, Pakistan. METHODS In summer 2002, five community-based eye camps were set up in Karachi, Pakistan's largest city. All individuals aged 30 ...

Diabetic retinopathy and nephropathy cause significant morbidity in patients with diabetes. Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor and is implicated in both of these diabetes complications. We previously reported transfection studies showing the VEGF -460 and VEGF +405 polymorphisms to increase basal VEGF promoter activity by 71% compar...

purpose : chlamydia pneumonia is a known endothelial pathogen in several vascular diseases including atherosclerosis, age-related macular degeneration and non-arteritic anterior ischemic optic neuropathy. diabetic retinopathy is a retinal vascular disease that may similarly be affected. we serologically investigated the presence of c. pneumonia infection in patients with proliferative diabetic ...

Diabetic retinopathy is the leading disease that occurs due to the diabetic mellitus. Several computer aided diagnosis helps ophthalmologists to diagnosis the severity of retinopathy but still the annual screening of retinal images is very important to detect diabetic retinopathy by an automatic assessment system for analyzing the images through region based method, filtering techniques, templa...

AIM To determine the staining pattern of vascular endothelial growth factor (VEGF) at different stages of diabetic retinopathy (including post-laser photocoagulation) and to compare staining in excised fibrovascular and fibrocellular (non-diabetic) preretinal membranes. METHODS Immunohistochemical localisation of VEGF, using antibodies raised against VEGF165 and VEGF121,165,189, was carried o...

Diabetic retinopathy is one of the leading cause of blindness caused due to increase of insulin in blood. It is a progressive disease and needs an early detection and treatment. Proliferative diabetic retinopathy is an advance stage and causes severe visual impairments. Early and accurate detection of proliferative diabetic retinopathy is very important and crucial for protection of patient’s v...

Epidemiologic and clinical studies have shown that diabetic retinopathy is a common chronic ocular disorder that developed in most type 2 diabetes. From the viewpoint of preventive medicine, the most crucial topic for preventing diabetic retinopathy is how to achieve early detection and appropriate treatment by using effective screening tools. To understand the morbidity of diabetic retinopathy...