Among the clinical presentation of plasma cell proliferative disorders the extramedullary plasmacytomas are the most infrequent after multiple myeloma and plasma cell tumours of the bones. The plasmacytoma of the thyroid gland to our knowledge has never been reported from Pakistan so far. We present the clinical picture and clinical challenges posed in diagnosis and treatment by this unusual pr...

Background & Objective The current study aimed to perform an immunohistochemical analysis of patterns of apoptotic and cell proliferative related protein expression in different histological grades and immune phenotypes of malignant lymphomas and other lymphoproliferative disorders. Methods This observational study was carried on 60lymph node biopsies of lymphoproliferative disorders. The bio...

conclusions juvenile xanthogranuloma is a cutaneous fibrohistiocytic lesion, which is rarely reported on palms. it is recommended to excise any soft tissue masses in children due to their possible association with malignancy. introduction juvenile xanthogranuloma (jxg) is a non-langerhans-cell histiocytosis, a group of histiocytic proliferative disorders, seen throughout the first two decades o...

By Northern blot analysis using a cDNA clone of the perforin gene, we studied the levels of perforin mRNA in peripheral blood mononuclear cells from 11 cases of granular lymphocyte-proliferative disorders (GLPDs). The granular lymphocytes studied were characterized by morphologic, immunophenotypic, and immunogenotypic analyses. Cytolytic functions of the lymphocytes assayed included nonmajor hi...

The normal process of dermal wound healing fails in some cases, due to fibro-proliferative disorders such as keloid and hypertrophic scars. These types of abnormal healing may be regarded as pathologically excessive responses to wounding in terms of fibroblastic cell profiles and their inflammatory growth-factor mediators. Biologically, these conditions are poorly understood and current medical...