A fall in blood pH was induced by intra-arterial infusion of HCl in seawater-adapted rainbow trout (Salmo gairdneri). The acute acidosis resulting from HCl infusion caused a short-lived decrease in plasma bicarbonate concentration ([HCO3-]) and an increase in arterial CO2 tension (PaCO2). Erythrocyte pH and bicarbonate concentrations were not significantly altered by the infusion of acid. Injec...

The objective of this study was to investigate and characterize incorporated propranolol HCl (Pro) within ethyl cellulose microparticle blends using the solvent evaporation method. were prepared with a water-in-oil-in-water (W/O/W) method contained same drug Propranolol (Pro). first Pro emulsion (W/O) second dispersed in an external aqueous phase, dispersion time interval (DTI) 0 60 min. morpho...

Disrupting reconsolidation may be promising in the treatment of anxiety disorders but the fear-reducing effects are thus far solely demonstrated in the average organism. A relevant question is whether disrupting fear memory reconsolidation is less effective in individuals who are vulnerable to develop an anxiety disorder. By collapsing data from six previous human fear conditioning studies we t...

BACKGROUND This study is based on the hypothesis, that the toxic or physiological effects of an optical isomer may be counteracted or reversed by the administration of a potentized preparation of one of its stereoisomers. In the present study the enantiomer was used. METHODS 154 ICR conventional mice were used. 77 mice were administered (R)-(+)-propranolol HCl homeopathic potency prior to and...

The model system propranolol hydrochloride (PROP-HCl)/AmberliteTM was studied in terms of equilibrium concentrations and amount drug bound to the ion exchanger, and compared to the system potassium chloride (KCl)/AmberliteTM. It was found that both the affinity and exchange capacity of AmberliteTM for PROP-H + ions is higher than for K + . Specific heat effects of the exchange reaction measured...

This simple, isocratic, normal-phase liquid-chromatographic method concurrently measures flecainide acetate and propranolol in 100 microL of serum within 8 min. The chromatographic system consists of a Waters "Resolve" column packed with 5-microns silica spheres and a mobile phase of ammonium sulfate (10 mmol/L, pH 6.8)/methanol (22/78 by vol), pumped at 0.9 mL/min and monitored by a fluoromete...

drug delivery via buccal mucosa by means of buccoadhesive formulations offer distinct advantages over peroral administration. recently, plant gums and exudates have been screened for their use as pharmaceutical adjuvants. the aim of this study is to evaluate matrix tablets containing plantago psyllium seed mucilage in addition to carbopol as a mucoadhesive agent, and propranolol hydrochloride a...