From the University of Michigan Medical Center, Ann Arbor, Mich. This work was supported by Grants from the Michigan Heart Association and U.S. Public Health Service, National Institutes of Health HE 07406-05. Manuscript received October 3, 1969, accepted February 6, 1970. Address for reprints: Ernest W. Reynolds, Jr., MD, University of Michigan Medical Center, Ann Arbor, Mich. 48104. Combining...

Kasabach-Merritt phenomenon (KMP) is relatively rare in childhood and adolescents with high mortality rate because of its hemorrhagic complications and unresponsiveness to treatments such as corticosteroids, vincristine, intravascular embolization, and/or surgery. Propranolol, a β -adrenergic receptor blocker, has a promising efficacy against vascular tumors such as infantile hemangiomas. But l...

PURPOSE to study the effect of Propranolol on hemodynamic response due to airway manipulation and carbon dioxide pneumoperitoneum on laparoscopic cholecystectomy cases. METHODS 63 patients undergoing laparoscopic cholecystectomy under general anaesthesia were randomly divided into 3 groups; group 1 received 1.0 mg of Propranolol, group 2 received 0.5 mg of Propranolol and group 3 received 1 m...

BACKGROUND Propranolol inhalation provocation tests are used to measure indirect airways responsiveness in the investigation of asthma. In this study the effects of repeated propranolol inhalation provocation tests within the same day on normal diurnal variation in the forced expiratory volume in one second (FEV1) and subsequent propranolol airways responsiveness were investigated. METHODS Fi...

There is no definitive conclusion regarding the optimal timing for terminating propranolol treatment for infantile hemangioma (IH). A total of 149 patients who underwent detailed color Doppler ultrasound examination were included in this study. The characteristics and propranolol treatment of all patients were summarized and analyzed. Patients were divided into two groups according to the lesio...

A 6-week-old girl was referred for management of a large left orbital and periorbital capillary hemangioma (Figure 1, Figure 2, Figure 3 and Figure 4; available at http://aaojournal.org). The neoplasm had been present since birth and getting progressively larger with resultant occlusive, anisometropic, and strabismic amblyopia of the left eye. She had received 1 intralesional steroid injection ...

Background—Postural Tachycardia Syndrome (POTS) induces disabling chronic orthostatic intolerance with an excessive increase in heart rate (HR) upon standing. Beta-blockade is an appealing treatment approach, but there are conflicting preliminary reports. We tested the hypothesis that propranolol will attenuate the tachycardia and improve symptom burden in patients with POTS. In Protocol #1, a ...

migraine involves 5-10% of children and adolescents. thirty percent of children with severe migraine attacks have school absence and reduced quality of life that need preventive therapy. the purpose of this randomised control trial study is to compare the effectiveness, safety and the tolerability of pregabalin toward propranolol in migraine prophylaxis of children. from may 2011 to october 201...

background: propranolol has been recently indicated to inhibit the rapid growth and involution of infantile hemangioma. in the present study, we investigated the efficacy and safety of propranolol in iranian infants. methods: a total of 30 infants with indications for medical intervention, such as large hemangiomas, wounds with or without secondary infection, or active trauma-induced bleeding, ...

Background: Propranolol has been recently indicated to inhibit the rapid growth and involution of infantile hemangioma. In the present study, we investigated the efficacy and safety of propranolol in Iranian infants. Methods: A total of 30 infants with indications for medical intervention, such as large hemangiomas, wounds with or without secondary infection, or active trauma-induced bleeding,...