1. Prostaglandin A-, prostaglandin E- and prostaglandin F-like substances were determined radioimmunologically in antral biopsy material obtained by endoscopy. 2. In patients with gastritis, the concentrations of prostaglandin (E+A)-like substances were six times as high and of prostaglandin F-like substances twice as high as in normal subjects. In chronic atrophic gastritis, the concentrations...

Prostaglandin synthetic activity of neural retina and retinal pigment epithelium in chick retina was studied using arachidonic acid and prostaglandin H2 (intermediate prostaglandin endoperoxide) as substrates. To obtain sufficient enzyme activity in retinal pigment epithelium, cultured chick retinal pigment epithelial cells were used. Little arachidonic acid was converted into prostaglandins, a...

BackgroundChronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings.ObjectiveThe aim of this study was to analyze the expression cytokines, prostaglandin (PG) synthases, and their receptors related pathogenesis CRS, especially those contributing nasal polyp (NP) formation.MethodsNPs uncinate tissue (UT) samples were collected from 90 patients who unde...

The formation of prostaglandins by prostaglandin H synthase can be limited by the availability of the fatty acid substrate or the hydroperoxide activator and also by a self-catalyzed inactivation associated with the oxygenation reaction. Each pmol of synthase appeared able to form only about 1300 pmol of prostaglandin from arachidonate before it was inactivated. This extent of synthesis was not...

the exact role of the epithelial lining of the trachea in modulating the bronchial tone is controversial. the present study was an attempt to verify the role of both prostaglandins and mast cells in the acute phase of acid inspiration in rat. four groups (n = 6) of n. mari rats were employed. the first group was used as placebo control, and normal saline was injected. to the second group hydroc...

Prostaglandins have been shown to play a role in carcinogenesis and the progression of many cancers, including prostate cancer. We have recently discovered that the biologically active form of vitamin D, 1,25(OH)2D or calcitriol, regulates multiple genes involved in the prostaglandin pathway. These effects include decreasing prostaglandin synthesis, increasing prostaglandin catabolism, and inhi...

Intra-amniotic injection of either prostaglandin F(2)alpha or prostaglandin E(2) was used in an attempt to induce therapeutic abortion in mid-pregnancy in 27 patients. Termination of pregnancy was successful in 11 out of 13 cases when prostaglandin E(2) alone was used, but in only 6 out of 14 cases when prostaglandin F(2)alpha was used. A further eight patients aborted after additional intraven...

1. Microsomal prostaglandin synthesis and tissue prostaglandin concentrations in the kidneys of rats made diabetic by pretreatment with alloxan or streptozotocin were significantly decreased but were unchanged in lungs. 2. Prostaglandin inactivation was increased in kidneys of alloxan-diabetic rats but not changed in streptozotocin-diabetic kidneys or in the lungs of either group. 3. These chan...

The initial product of the interaction between prostaglandin A(1) and the prostaglandin isomerase of cat blood plasma has been isolated. By ultraviolet spectroscopy and mass spectrometry and from stability and chromatographic studies, the structure of the compound has been established as 15-hydroxy-9-oxoprosta-11,13-dienoic acid, an allylic isomer of prostaglandin A(1). The compound is unstable...

background: to compare the efficacy of two routes of prostaglandin e 2 administration (intravenous and intramuscular) for treatment of missed abortion this study was conducted. regarding the pilot cases of missed abortion admitted for termination of pregnancy intravenous administration of pge2 that had higher efficacy compare to intramuscular route, investigators designed this study. methods: i...