Vascular and lymphatic malformations represent a challenge for clinicians. The identification of inherited somatic mutations in important signaling pathways, including the PI3K (phosphoinositide 3-kinase)/AKT (protein kinase B)/mTOR (mammalian target rapamycin), RAS (rat sarcoma)/RAF (rapidly accelerated fibrosarcoma)/MEK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated ki...

Abstract: Aim: LK (B-lymphocyte kinase) is a protein from the family SRC (Proto-oncogene tyrosine-protein kinase), an important cell signaling molecule that influences cellular response. The BLK kinase has been potential target for cancer therapy. As result, this could be initial step toward development of novel inhibitors to fight cancer. Materials and Methods: A homology model human tyrosine ...

Piperine is a dietary alkaloid with huge pharmacological importance and was first isolated from pepper extract. It has been reported anti-cancer, anti-amoebic, anti-mycobacterial, anti-mutagenic, anticonvulsant, anti-asthmatic, immunomodulatory, anti-inflammatory anti-oxidant activity. Therefore, the current investigation designed to unveil anticancer effects of piperine molecule against human ...

Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice.Materials and Methods: Thirty mice were randomly assigned int...

long-term potentiation (ltp) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. studies in recent years indicate the importance of molecular pathways in the development of memory and learning. tropomyosin receptor kinase b (trkb) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

Liver fibrosis is an outcome of many chronic liver diseases and often results in cirrhosis, failure even hepatocarcinoma. Zhuyu zhenggan decoction as a classical traditional Chinese medicine formula used to clinical practice while its mechanism unclear. The aim this study was investigate the anti-fibrosis effect explore molecular mechanisms by combining network pharmacology animal experiment. c...

It first came to prominence... in the mid 1990s, when it was shown that PKB is regulated by PI 3-kinase, a lipid kinase that everyone was trying to find effectors for. Is that it? No. The really big excitement came when it transpired that PKB, through the actions of PI 3-kinase, transmits a survival signal that allows cells to suppress apoptosis. Strangely, only two studies have shown a direct ...

antiproliferative protein (app) isolated from conditioned media of two androgen-independent prostatic carcinoma cell lines, pc3 and du-145 was shown to inhibit selectively cell proliferation of androgen-dependent prostate cancer cell line lncap in a dose dependent manner. this protein was further purified with hplc using hydrophobic interaction column (phenyl 5pw) and was used to study the modu...