Withania somnifera (L.) Dun. (Solanaceae), known as Indian ginseng, is one of the most popular medicinal plants in India. Considering the importance and common use of this plant, it is necessary to investigate its holistic metabolite profile. However, with existing analytical methods which are based on TLC and HPLC‑UV (or MS), it is difficult to obtain information of the whole range of compound...

Objective: The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology. Materials and Methods: In the present study, arsenic in the form of sodium arsenite was administered orally ...

Antioxidants are the essential defense mechanism to protect the body against free radical damage. The objective of the study was to investigate the in vitro antioxidant activity of different parts of Withania somnifera (leaves, fresh tubers and dry tubers) towards free radical DPPH and the extent of inhibition of lipid peroxidation using hydrogen peroxide as prooxidant. The plant extracts exhib...

In vitro multiple shoots, root, callus and cell suspension cultures of Withania somnifera exhibited the potentiality to produce pharmacologically active withanolides. Multiple shoots cultures exhibited an increase in withanolide A accumulation compared to shoots of the mother plant. In vitro generated root cultures as well as callus and suspension cultures also produced withanolides albeit at l...

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1. The Indian Herbal Pharmacoepia. Regional Research Laboratory and Indian Drug Manufacturers Association. Mumbai: IDMA; 2002. p. 467. 2. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol 1999;64:91-3. 3. Jha NK, Jha AK. Bacopa monnieri: Brahmi. Phytopharm 2005;11:3-14. 4. Gupta AP, Mathur S. High performance thin layer chromatography method for determination...

background urinary tract infections (uti) caused by resistant bacteria are becoming more prevalent. the spread of extended-spectrum beta-lactamase (esbl)-producing bacteria worldwide has become a serious public health issue among healthcare centers and in the community. drugs and many secondary metabolites from medicinal plants have proved to be economical and effective against many pathogens. ...

Phytochemical and Pharmacological Profile of Withania somnifera Dunal: A ReviewQamar Uddin, L. Samiulla, V. K. Singh, S. Jamil

Aim The present study was conducted to explore the effect of supplementation of Withania somnifera and synbiotics alone or in combination on the composition of broiler breast meat under heat stress conditions. Materials and Methods A 42-day feeding trial was conducted on 360 broiler chicks randomly allotted into eight treatment groups with three replicates each under completely randomized des...