www.landesbioscience.com Cell Cycle 3457 Disease modeling using induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) promises to reveal underlying pathophysiology, especially for genetic diseases that manifest pathologic tissue development, or in cases where disease tissues are largely destroyed by disease at the time of diagnosis. Shwachman–Diamond syndrome (SDS), a ra...

screening and identification of moderately halophilic protease producing bacteria from different regions of maharloo, a hypersaline lake in the southern area of iran, were the objectives of this study. in the preliminary screening, 16 isolates exhibited proteolytic activity on saline skim milk agar. all isolates were able to grow comfortably in the media containing 7-15% of salt. protease activ...

proteases catalyze the hydrolysis of peptide bonds in proteins. they are widely distributed in nature, nearly in all plants, animals and microorganisms. plant latex is a rich source of proteases. latex production is unique property of euphorbian plant, which could be a potential source of proteolytic enzymes. the highest proteolytic activity was observed in the latex of pedilanthus tithymaloide...

Gibberellin (GA) hormone signaling occurs through proteolytic and non-proteolytic mechanisms. GA binding to the GA receptor GID1 (GA-INSENSITIVE DWARF1) enables GID1 to bind negative regulators of GA responses called DELLA proteins. In proteolytic GA signaling, the SLEEPY1 (SLY1) F-box protein targets DELLA proteins in the GID1-GA-DELLA complex for destruction through the ubiquitin-proteasome p...

      Screening and identification of moderately halophilic protease producing bacteria from different regions of Maharloo, a hypersaline lake in the southern area of Iran, were the objectives of this study. In the preliminary screening, 16 isolates exhibited proteolytic activity on saline skim milk agar. All isolates were able to grow comfortably in the media containing 7-15% of salt. Protease...

Here, we report the discovery of first plant-derived and noncanonical epidermal growth factor receptor (EGFR) agonist, 36-residue bleogen pB1 from Pereskia bleo Cactaceae family. We show that is a low-affinity EGFR agonist using suite chemical, biochemical, cellular, animal experiments which include incisor eruption wound-healing mouse models. A focused positional scanning library Ala- d-amino ...

The migration of different cell types, such as leucocytes and tumour cells, involves cellular strategies to overcome the physical resistance of three-dimensional tissue networks, including proteolytic degradation of extracellular matrix (ECM) components. High-resolution live-cell imaging techniques have recently provided structural and biochemical insight into the differential use of matrix-deg...