BACKGROUND We characterize a novel nanocomposite that acts as an efficient anticancer agent. METHODS This nanocomposite consists of zinc layered hydroxide intercalated with protocatechuate (an anionic form of protocatechuic acid), that has been synthesized using a direct method with zinc oxide and protocatechuic acid as precursors. RESULTS The resulting protocatechuic acid nanocomposite (PA...

the Neuro8pora or bacterial mutants. In addition, it seems improbable on structural grounds that these benzenoid compounds would be intermediates in the synthesis of such hydroaromatic compounds as prephenic acid. It is not known at present whether vanillic acid is formed by methylation of the 3-hydroxyl group of dehydroshikimic acid followed by dehydration, or by direct methylation of protocat...

Protocatechuic acid (3,4-dihydroxybenzoic acid, PCA) is a simple phenolic acid. It is found in a large variety of edible plants and possesses various pharmacological activities. This article aims to review the modern trends in phytochemical isolation and extraction of PCA from plants and other natural resources. Moreover, this article also encompasses pharmacological and biological activities o...

The mechanism of biosynthesis of the simpler aromatic compounds has been significantly clarified recently by the use of mutant strains of Neurospora (1) and Escherichia coli (2) and by the use of isotopic carbon (3-6). The evidence indicates that aromatization takes place via dehydroquinic acid, dehydroshikimic acid, and shikimic acid. Although the ultimate source of the carbon atoms of the aro...

3and 4-monoesterified protocatechuic acid methyl ester (5 and 7 respectively) have been synthesised from quinic acid by a high yields biomimetic rearrangement.

Persistent hyperglycemia, impairment of redox status and establishment of inflammatory pathophysiology integrally play important role in the pathogenesis of diabetic cardiomyopathy (DC). Present study examined the therapeutic potential of protocatechuic acid isolated from the Sansevieria roxburghiana rhizomes against DC employing rodent model of type 2 diabetes (T2D). T2D was induced by high fa...

Ammonia-lyase activity for L-phenylalanine, m-hydroxyphenylalanine and L-tyrosine was demonstrated in cell-free extracts ofSporobolomyces roseus. Cultures of this organism converted DL-[ring-14C]phenylalanine and L-[U-14C]tyrosine into the corresponding cinnamic acid. Tracer studies showed that these compounds were further metabolized to [14C]protocatechuic acid. Benzoic acid andp-hydroxybenzoi...

The objective of this study was to determine the effect on fatty acid composition of heating olive and sunflower oils with selected natural and synthetic antioxidants. The antioxidants investigated were quercetin, caffeic acid, protocatechuic acid, and butylated hydroxyanisole (BHA), each at concentrations of 0.02, 0.04, and 0.06%. Oils with no added antioxidants were also heated. After heating...

In a paper recently published in this Journal (1) we reported the isolation of the phenolic acid commonly known as protocatechuic acid (3,4-dihydroxybenzoic acid) from the outer bulb scales of pigmented onions. The occurrence of this acid in the outer scales has a significant relationship to disease resistance in the onion. Protocatechuic acid is apparently one of the chemical entities that ena...