Dugesia tigrina is a non-parasitic platyhelminth, which has been recently utilized in pharmacological models, regarding the nervous system, as it presents a wide sensitivity to drugs. Our trials aimed to propose a model for an in vivo screening of substances with inhibitory activity of the enzyme acetylcholinesterase. Trials were performed with four drugs commercialized in Brazil: donepezil, ta...


 Значне поширення резистентних штамів P. aeruginosa, здатність до плівкоутворення, складні регуляторні мережі формування біоплівок і багаточисельні фактори вірулентності потребують пошуку нових сполук розробки препаратів, які здатні порушувати біоплівок.
 Мета дослідження – вивчити експресію генів, що регулюють біоплівки aeruginosa за дії похідного адамантану.
 Антибіоплівкову а...

objective(s): the aim of this study was to investigate the methylation status and mrna expression levels of p15, death-associated protein kinase (dapk), and suppressor of cytokine signaling-1 (socs1) genes in multiple myeloma (mm). materials and methods: the bone marrow samples of 54 mm patients were collected and the methylation status of the p15, dapk, and socs1 gene promoter regions was dete...

conclusions some results of the correlation coefficients are not the same with visualization. the reason may be due to the small number of data. materials and methods in the foundation-application study, we constructed two-way gene networks using nonparametric methods, such as spearman’s rank correlation coefficient and blomqvist’s measure, and compared them with pearson’s correlation coefficie...

in view of the fundamental role of genetics in development of obesity, the present study aimed to investigate the single nucleotide polymorphism of some obesity-related genes among a subset of obese women living in tabriz, iran. for this purpose, 70 eligible obese women (aged 18-45 years) were genotyped for the uncoupling protein-1 (ucp-1) -3826a>g, ß3-adrenergic receptor (ß3adr) trp64arg, lept...

In this month’s issue of the Journal of Bacteriology, Jones et al. (1) examine the relationship between the Pseudomonas aeruginosa chronically produced exopolysaccharide, alginate, and a polysaccharide that is produced during the initial stages of biofilm formation, Psl. Psl, composed of mannose, rhamnose, and glucose, was identified as one of the first exopolysaccharides in nonmucoid biofilm m...

many factors including genetic, environmental, and acquired are involved in breast cancer development across various societies. among all of these factors in families with a history of breast cancer throughout several generations, genetics, like predisposing genes to develop this disease, should be considered more. early detection of mutation carriers in these genes, in turn, can play an import...