PURPOSE OF REVIEW Evidence-based therapies and guidelines for pulmonary arterial hypertension are critiqued. RECENT FINDINGS Morbidity and mortality in pulmonary arterial hypertension reflects failure of right ventricular compensation for increased afterload caused by obstructive pulmonary arterial remodeling. This predominantly reflects excessive proliferation/impaired apoptosis of smooth mu...

Although pulmonary arterial hypertension is usually associated with advanced stages of sarcoidosis, its occurrence in early stage disease is rare. Herein, a case of associated pulmonary arterial hypertension in the setting of Hashitoxicosis and stage II pulmonary sarcoidosis is reported. The case of associated pulmonary arterial hypertension occurred in a young female without clinically signifi...

The severity of pulmonary hypertension was evaluated by right cardiac catheterization in 89 patients with stable chronic obstructive pulmonary disease, both at rest and during maximum treadmill exercise. Thirty-one patients were found to have pulmonary hypertension at rest, defined as a mean pulmonary arterial pressure of 20 mm Hg or more. Although the remaining 58 patients had normal mean pulm...

Pulmonary arterial hypertension in children. A. Widlitz, R.J. Barst. #ERS Journals Ltd 2003. ABSTRACT: For physicians to admit that a group of patients remains for whom no cure is available in modern medicine is intellectually unsatisfying. Pulmonary arterial hypertension is a rare condition. Because the symptoms are nonspecific and the physical finding can be subtle, the disease is often diagn...

introduction pulmonary vein stenosis includes narrowing of one or more pulmonary veins that may have congenital or acquired causes. congenital pulmonary vein stenosis is a rare condition and also a rare cause for pulmonary hypertension. since identifying the etiology of pulmonary hypertension plays a crucial role in medical and surgical planning, we decided to introduce a rare case of pulmonary...

conclusions the results of the first human pharmacokinetic studies of aminorex were first characterized in 2013. the results suggest that while humans could produce aminorex from levamisole, they probably do not convert very much. even though cases of pah have been reported in cocaine users, the latest pharmacokinetic studies suggest that very little aminorex is actually produced from the inges...

Pulmonary arterial hypertension is defined as a mean pulmonary arterial pressure greater than 25 mm Hg at rest or 30 mm Hg during physical activity. Pulmonary arterial hypertension is classified into subgroups, including idiopathic, heritable, and pulmonary arterial hypertension associated with other conditions. A detailed history, thorough physical examination, and most importantly, a high ind...

the purpose of this investigation was to assess the effect of captopril on both systemic (p.a) and pulmonary arterial pressures (ppa) in patients with high-altitude pulmonary hypertension (haph). seventeen patients (mean age 44±6.8 years) with haph and mild to moderate systemic arterial hypertension were included in the study. all patients underwent right heart catheterization with measurements...

BACKGROUND Interferon alpha2 is widely used in hepatitis and high-risk melanoma. Interferon-induced pulmonary arterial hypertension as a side effect is rare. CASE PRESENTATION We describe a melanoma patient who developed severe pulmonary arterial hypertension 30 months after initiation of adjuvant interferon alpha2b therapy. Discontinuation of interferon did not improve pulmonary arterial hyp...

Vitamin K antagonists are advised in pulmonary arterial hypertension patients despite a lack of safety data. We reviewed major bleeding in three classes of pulmonary hypertension patients, all receiving vitamin K antagonists. Bleeding event rates were 5.4 per 100 patient-years for patients with idiopathic pulmonary arterial hypertension, 19 per 100 patient-years for connective tissue disease re...