To assess the effects of vasopressors on plasma levels of immunoreactive atrial natriuretic factor (ANF), 13 normal men were studied on two occasions. On the experimental day, subjects received sequential 15-minute intravenous infusions of angiotensin II in doses of 4, 8, and 16 pmol/kg/min. Following a 30-minute recovery period, subjects received sequential 15-minute infusions of phenylephrine...

The interrelationship of hydrostatic pressure and osmotic forces across the capillary membrane are described by the Starling equation [lo]. Increasing pulmonary capillary hydrostatic pressure is a cause of pulmonary edema 131. Pulmonary edema develops at a lower hydrostatic pressure when plasma colloid oncotic pressure is lowered suggesting that the gradient between colloid oncotic pressure (CO...

RATIONALE Abnormalities in nitric oxide signaling play a pivotal role in heart failure with preserved ejection fraction (HFpEF). Intravenous sodium nitrite, which is converted to nitric oxide in vivo, improves hemodynamics in HFpEF, but its use is limited by the need for parenteral administration. Nitrite can also be administered using a novel, portable micronebulizer system suitable for chroni...

The results of this study showed an advantage of nesiritide compared with high-dose nitroglycerin in the treatment of patients with decompensated heart failure. Nesiritide resulted in an early decrease in pulmonary capillary wedge pressure (< or =15 minutes), which was sustained throughout the study period (24 hours) without the need for up-titration. In contrast, the onset of the nitroglycerin...

Fifteen patients with acute myocardial infarction and an elevated pulmonary capillary wedge pressure were given 40 mg furosemide intravenously within 24 hr of diagnosis of infarction. We divided the patients into two groups on the basis of the diuretic response to furosemide: nine who responded with a diuresis of greater than 400 ml in two hours, and six with a lower diuresis. The nine patients...

Background. This study investigates the effects of sodium nitroprusside on regional vascular capacitance in eight patients with severe congestive heart failure (New York Heart Association class IV) and pulmonary hypertension. Methods and Results. Regional relative blood volumes in the splanchnic and pulmonary region were determined by equilibrium blood pool scintigraphy. Hepatic venous wedge pr...

BACKGROUND This study investigates the effects of sodium nitroprusside on regional vascular capacitance in eight patients with severe congestive heart failure (New York Heart Association class IV) and pulmonary hypertension. METHODS AND RESULTS Regional relative blood volumes in the splanchnic and pulmonary region were determined by equilibrium blood pool scintigraphy. Hepatic venous wedge pr...

APRESSURE recorded through a cardiac catheter wedged tightly in a small . pulmonary artery has been referred to as a "capillary," "venous" or "wedge" pressure. On the other hand, a pressure recorded through a cardiac catheter wedged into a pulmonary vein during thoracotomy and in intact animals has been referred to as a pulmonary venous wedge pressure'. Some investigators have found good correl...

Background Right ventricular-pulmonary arterial coupling plays an important role in the occurrence of right ventricular failure. Ventricular-arterial coupling is defined as Ea/ Emax. Ea is the effective arterial elastance and an index of the post-load, and includes vascular resistances, vessel compliance, vascular impedance, systolic and diastolic time intervals. Ea = (arterial end-systolic pre...