BACKGROUND Pulmonary hypertension is a hallmark of high-altitude pulmonary edema and may contribute to its pathogenesis. When administered by inhalation, nitric oxide, an endothelium-derived relaxing factor, attenuates the pulmonary vasoconstriction produced by short-term hypoxia. METHODS We studied the effects of inhaled nitric oxide on pulmonary-artery pressure and arterial oxygenation in 1...

• Clinically, the development of pulmonary edema is frequently associated with an elevation of left atrial pressure. However, overt pulmonary edema does not always occur with such pressure elevations, even when the plasma oncotic pressure is greatly exceeded. It is conceivable that a dilatation of the pulmonary lymphatic system might remove fluid from the lung and prevent, or delay, the develop...

• Clinically, the development of pulmonary edema is frequently associated with an elevation of left atrial pressure. However, overt pulmonary edema does not always occur with such pressure elevations, even when the plasma oncotic pressure is greatly exceeded. It is conceivable that a dilatation of the pulmonary lymphatic system might remove fluid from the lung and prevent, or delay, the develop...

The occurrence of cardiogenic pulmonary edema following alternating current electrical injury has not been reported. A patient developing severe pulmonary edema immediately following an electrical injury-induced episode of ventricular fibrillation is described. Evidence that the etiology of the pulmonary edema was cardiogenic is derived from both hemodynamic data and the calculation of the pulm...

Pulmonary artery wedge and plasma colloid osmotic pressures and their relationship to pulmonary edema were investigated in 26 patients with acute myocardial infarction of whom 14 developed pulmonary edema. In the absence of pulmonary edema, both the pulmonary artery wedge pressure and plasma colloid osmotic pressure were in normal range; after onset pulmonary edema, a moderate increase in pulmo...

Cardiac catheterization was performed on seven children after recovery from highaltitude pulmonary edema. All were life-long residents at elevations above 10,000 feet. Three of the seven had developed pulmonary edema without antecedent travel to low altitude but had an upper respiratory infection. Response of pulmonary arterial pressure to 16% inspired oxygen in all seven was compared with that...

The pulmonary edema that develops quickly after a variety of cerebral insults, such as head injury, epileptic seizures, intracranial hypertension, and subarachnoid hemorrhage, is often accompanied by rapid flooding of airways with a protein-rich edema fluid (Weisman, 1939; MacKay, 1950; Richards, 1963; Simmons et al., 1968; Ciongoli and Posner, 1972; Theodore and Robin, 1976; Fisher and AboulNa...

The pulmonary edema that develops quickly after a variety of cerebral insults, such as head injury, epileptic seizures, intracranial hypertension, and subarachnoid hemorrhage, is often accompanied by rapid flooding of airways with a protein-rich edema fluid (Weisman, 1939; MacKay, 1950; Richards, 1963; Simmons et al., 1968; Ciongoli and Posner, 1972; Theodore and Robin, 1976; Fisher and AboulNa...