The antidiarrheal effects of the aqueous extract of Punica granatum L. (Punicaceae) peels were evaluated in rats. Studies were carried out on the isolated rat ileum, gastrointestinal motility in vivo, and on castor oil–induced diarrhea in rats. The results revealed that the extract exhibited a concentration-dependent inhibition of the spontaneous movement of the isolated rat ileum and attenuate...

Punica granatum L. has a long standing culinary and medicinal traditional use in Mauritius. This prompted a comparative study to determine the bioefficacy of the flower, peel, leaf, stem, and seed extracts of the Mauritian P. granatum. The flower and peel extracts resulting from organic solvent extraction exhibited strong antioxidant activities which correlated with the high levels of total phe...

Dementia is one of the age related mental problems and characteristic symptom of various neurodegenerative diseases including Alzheimer's disease. This impairment probably is due to the vulnerability of the brain cells to increased oxidative stress during aging process. Many studies have shown that certain phenolic antioxidants attenuate neuronal cell death induced by oxidative stress. The pres...

The present study has been designed to explore the beneficial effect of Punica grantum leaves in experimental cardiac hypertrophy in rats. Punica granatum L., (Family: Punicaceae) is used in Indian Unani medicine for treatment of diabetes mellitus, cytotoxixity and in wound healing owing to its antioxidant activity. The male wistar rats were anaesthetized with thiopentone sodium and were subjec...

PURPOSE Punica granatum L. var. granatum (Pomegranate), an herbaceous plant found in Iran, The aim of this study was to investigate the cytotoxic effects, induction of apoptosis, and the mechanism of cell death of ethanol extract from Punica granatum L. var. spinosa on the mouse fibrosarcoma cell line, WEHI-164. METHODS Various parts of the herbs were extracted from fruit using ethanol as the...

TAMAE YODA,1 LARRY I. CRAWSHAW,2 KYOKO YOSHIDA,1 LIU SU,1 TAKAYOSHI HOSONO,2 OSAMU SHIDO,3 SOTARO SAKURADA,3 YUTAKA FUKUDA,1 AND KAZUYUKI KANOSUE2 1Department of Physiology and Biosignalling, Graduate School of Medicine, Osaka University, Osaka; 2Department of Physiology, School of Allied Health Sciences, Osaka University Faculty of Medicine, Osaka 565-0871; and 3Department of Physiology, Schoo...

BACKGROUND Rind of Punica granatum is traditionally used in treatment of abdominal cramps and various GIT disorders. So far spasmolytic activity of rind of Punica granatum has been reported using in vitro model. However, its mode of action is not explored yet. Therefore, the current work describes the possible mode of action for spasmolytic activity of methanolic extract of rind of Punica grana...

The ethnobotanical survey conducted in this study showed that 21 plant species belonging to 14 families are used in traditional medical practice in Limpopo Province, South Africa, for the treatment of diarrhoea. Methanol, ethanol, acetone and hot water extract from different plant parts (leaves, roots, bark and stem rhizome), of several of these plants (Indigofera daleoides, Punica granatum, Sy...

Diarrheal diseases are a leading cause of mortality and morbidity especially among children in developing countries resulting in a major health care problem. Medicinal plants constitute the major component of traditional medicine practiced worldwide due to the economical viability, accessibility, and ancestral experience. Two medicinal plants (Punica granatum, Syzygium cumini) used in diarrheal...