OBJECTIVES Amphotericin B (AmB) is a drug of choice for treatment of disseminated fungal infections, but its use is often associated with severe adverse effects. Our observation that generic formulations of AmB contain multiple polyene components led us to propose that removal of other polyenes would yield a high purity AmB (AmBHP) with an improved therapeutic index. METHODS To test that prem...

Adámek and Sousa recently solved the problem of characterizing the subcategories K of a locally λ-presentable category C which are λ-orthogonal in C, using their concept of Kλ-pure morphism. We strenghten the latter definition, in order to obtain a characterization of the classes defined by orthogonality with respect to λ-presentable morphisms (where f :A B is called λ-presentable if it is a λ-...

We consider smooth completion of algebraic manifolds. Having some information about its singular completions or about completions of its images we prove purity of cohohomology of the set at infinity. We deduce also some topological properties. The work is based on the study of perverse direct images for algebraic maps.

Many mathematicians have sought ‘pure’ proofs of theorems. There are different takes on what a ‘pure’ proof is, though, and it’s important to be clear on their differences, because they can easily be conflated. In this paper I want to distinguish between two of them. I want to begin with a classical formulation of purity, due to Hilbert: In modern mathematics one strives to preserve the purity ...

Motivated by a concrete goal, namely to extend Erlang with the ability to employ user-defined guards, we developed a parameterized static analysis tool called PURITY, that classifies functions as referentially transparent (i.e., sideeffect free with no dependency on the execution environment and never raising an exception), side-effect free with no dependencies but possibly raising exceptions, ...

The study was attempted with an objective to check the purity of commonly used farmer’s rice seed stock. Assessment of varietal purity of collected 76 rice genotypes showed that there was a variation among the genotypes for varietal purity. Thirty-two genotypes showed 100% varietal purity and forty-four genotypes were contaminated with different types of offtypes. The lowest varietal purity was...