Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show that following left coronary artery ligation, mice with a targeted deletion of the S-nitrosoglutathione reductase gene (GSNOR(-/-)) have reduced myocardial infarct size, preserved ve...

Gut microbes positively affect the physiology of many animals, but the molecular mechanisms underlying these benefits remain poorly understood. We recently reported that bacteria-induced gut hypoxia functions as a signal for growth and molting of the mosquito Aedes aegypti In this study, we tested the hypothesis that transduction of a gut hypoxia signal requires hypoxia-induced transcription fa...

1. Decision making and operations research. (a) The need for optimization. (b) Typical models of industry and finance. 2. Advanced linear programming (LP) (a) Need for linear models. (b) General form of LP problems. (c) The sparse simplex method; primal and dual algorithms; computational implications. (d) Economic interpretation of the optimality conditions: Sensitivity analysis. (e) Interior p...

This paper considers the body of observational evidence examining the association of being breast-fed to cardiovascular risk factors and outcomes in later life, and whether any potentially advantageous findings are causal. Early cardiovascular consequences/correlates of breastfeeding, compared to being formula fed, include markedly higher levels of total blood cholesterol, lower levels of pre-p...

BACKGROUND Our previous study revealed that the combination of Saikosaponin-d ( SSd) and radiation is more effective in the treatment of liver cancer than the application of either of these monotherapeutic methods. However, the molecular mechanisms of the radiosensitizing effect of SSd on liver cancer remained ill defined. METHODS Cells were treated with different interventions; afterward, ce...

Introduction Dynamic contrast-enhanced (DCE)-MRI is a functional imaging method that is often used to quantify changes in tumor microvasculature in small animal models of cancer. Unfortunately, the relatively long imaging protocol results in high costs for imaging, a limited number of animals that can be scanned over a given time interval, and logistical complications that can dominate the desi...

Poor prognosis of glioblastoma multiforme is strongly associated with the ability of tumor cells to invade the brain parenchyma, which is believed to be the major factor responsible for glioblastoma recurrence. Therefore, identifying the molecular mechanisms driving invasion may lead to the development of improved therapies for glioblastoma patients. Here, we investigated the role of procollage...