[3+2] Cycloaddition of azomethine imines with electron-deficient terminal alkynes was smoothly catalyzed by a chiral bis(imidazolidine)pyridine-CuOAc complex to give bicyclic pyrazolo[1,2-a]pyrazolone derivatives with up to 74% ee.

The title Schiff base compound, C(22)H(24)IN(3)O(2), adopts an E configuration about the central C=N bond. The pyrazolone ring makes a dihedral angle of 49.68 (10)° with its attached phenyl ring. The phenolate plane makes dihedral angles of 16.78 (9) and 50.54 (9)°, respectively, with the pyrazolone ring and the terminal phenyl ring. An intra-molecular C-H⋯O hydrogen bond generates an S(6) ring...

The title compound, C(20)H(16)Cl(2)N(4)O, has two mol-ecules in the asymmetric unit. The two five-membered rings form a dihedral angle of 54.2 (3)° in one mol-ecule and 56.8 (3)° in the other independent mol-ecule. The amino group of the dihydro-pyrazolone unit of one mol-ecule acts as a hydrogen-bond donor to the carbonyl group of the dihydro-pyrazolone system of the other mol-ecule. The resul...

In the title compound C27H22Cl2N4O2, the pyrazol-5-ol ring makes a dihedral angle of 34.80 (11)° with the phenyl ring to which it is bound, while the pyrazolone ring is inclined at 34.34 (12)° to its attached phenyl ring. In the crystal, N-H⋯O and C-H⋯Cl hydrogen bonds link the mol-ecules into chains along [010]. Inter-molecular π-π inter-actions are observed between the pyrazolone ring and the...

In the title compound, C(25)H(22)BrN(3)O(5)S, the central benzene ring makes dihedral angles of 32.02 (14), 37.49 (18) and 80.52 (13)°, respectively, with the pyrazolone ring, the bromo-benzene ring and the terminal phenyl ring. This conformation features a short intramolecular C-H⋯O contact that generates an S(6) ring. In the crystal, inversion dimers linked by pairs of C-H⋯O=C hydrogen bonds ...

In the title compound, C(26)H(23)N(5)O(7), the central benzene ring makes dihedral angles of 35.08 (6), 48.75 (7) and 69.55 (8)° with the pyrazolone ring, the nitro-benzene ring and the terminal phenyl ring, respectively. An intra-molecular C-H⋯O inter-action generates an S(6) ring. The packing is stabilized by weak nonclassical inter-molecular C-H⋯O=C hydrogen bonds that link adjacent mol-ecul...

Penelitian ini bertujuan untuk mengembangkan media pembelajaran program simulasi ekstraksi pelarut dan spektrofotometri UV-Vis pada logam lantanida menggunakan ekstraktan 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone berbasis Microsoft Excel, serta menguji kelayakan tanggapan mahasiswa terhadap yang dikembangkan. Jenis penelitian digunakan adalah pengembangan (RD), dengan tujuh langkah yaitu; (1) po...

The arylsulfanylpyrazolone and aryloxanylpyrazolone scaffolds previously were reported to inhibit Cu/Zn superoxide dismutase 1 dependent protein aggregation and to extend survival in the ALS mouse model. However, further evaluation of these compounds indicated weak pharmacokinetic properties and a relatively low maximum tolerated dose. On the basis of an ADME analysis, a new series of compounds...

Starting from N-substituted indole-3-carboxaldehydes (1a-g) a series of new 3-[(N-substituted indol-3-yl)methyleneamino]-6-amino-4-aryl-pyrano(2,3-c)pyrazole-5-carbonitriles (3a-g and 4a-g) have been synthesized via the acid catalyzed condensation reaction of 1a-g with 3-amino-5-pyrazolone, followed by the reaction with arylidene malononitriles. A series of new 3,6-diamino-4-(N-substituted indo...

Complexes derived from some 1-Phenyl-3-methyl-4-nitroso-5-pyrazolone (L1), 1,3-diphenyl-4nitroso-5-pyrazolone (L2) and 1-phenyl-3-anilino4-nitroso-5-pyrazolone (L3) with Mn, Co, Ni, Cu and Zn metal ions have been prepared. Structural investigation of the ligands and their complexes has been made based on elemental analysis, infrared (FT-IR), ultraviolet and visible spectra (UV-Vis.), proton nuc...