The asymmetric unit of the title compound, 2C13H14N2O3·C3H10NO3 (+)·Cl(-), contains two independent mol-ecules (A and B) of the title pyrimidine derivative and one ion-pair of tris-(hy-droxy-meth-yl)ammonium chloride. The pyrimidine ring in each pyrimidine derivative has a half-chair conformation. Its mean plane is inclined to the benzene ring by 87.2 (3)° in mol-ecule A and 85.7 (2)° in mol-ec...

The title pyrimidine derivative, C(18)H(21)N(3)O(6), was obtained by the reaction of methyl 2-[2-(benzyl-oxycarbon-yl)amino-propan-2-yl]-5-hy-droxy-6-oxo-1,6-dihydro-pyrimidine-4-carboxyl-ate with dimethyl sulfate in dimethyl sulfoxide. The mol-ecule has a V-shaped structure, the phenyl and the pyrimidine rings making a dihedral angle of 43.1 (1)°. The methyl group substituting the pyrimidine r...

The catalysis, by the enzyme thiaminase, of reversible baseexchange reactions between thiamine and aromatic tertiary amines was first reported by Fujita et al. (1). Related findings with mammalian diphosphopyridine nucleotidases (2) and with methionine activation (3) drew attention to the energy-rich nature of “onium” (4-6) compounds and suggested that the alkylation of thiazole must involve ac...

Novel N-methoxymethylated (MOM) pyrimidine (4-13) and pyrimidine-2,4-diones (15-17) nucleoside mimetics in which an isobutyl side-chain is attached at the C-6 position of the pyrimidine moiety were synthesized. Synthetic methods via O-persilylated or N-anionic uracil derivatives have been evaluated for the synthesis of N-1- and/or N-3-MOM pyrimidine derivatives with C-6 acyclic side-chains. A s...

A pyrimidine chromophore bearing an acridan fragment was synthesized and its photophysical properties were studied. In solution, this compound is characterized by important positive emission solvatochromism with a shift of 5800 cm-1 between nonpolar heptane dichloromethane (DCM) associated large Stokes shifts (up to 9100 in DCM). Mono-exponential fluorescence decays are observed whereas more co...