Pyrimidines represent an important class of heterocycles containing two nitrogen atoms at position 1 and 3 the six membered ring show wide range biological activities. Numerous methods for synthesis pyrimidine their diverse reactions offer enormous scope in field medicinal chemistry. Pyrimidine possesses spectrum activities including antitubercular, antibacterial, antifungal, antiviral, anti-in...

The distribution of purines and pyrimidines in desoxypentose nucleic acids prepared from a variety of animal and plant sources has been studied. 1. The nucleic acids were prepared from calf thymus, calf kidney, sheep spleen, horse spleen, chicken erythrocyte, turtle erythrocyte, trout sperm, shad testes, sea urchin sperm, wheat germ, and Pneumococcus Type III. 2. Separate hydrolyses were carrie...

a practical and new method for the synthesis oxindole substituted pyrrolo[2,3-d]pyrimidines by the condensation of isatin, acetophenone and 6-amino-uracil under ultrasound irradiation conditions at 60 °c was described. the reaction was developed via a sequential tandem process to afford the oxindole substituted pyrrolo[2,3-d]pyrimidines in good to excellent yields. all reactions performed effic...

Biginelli-type pyrimidines contain an interesting moiety which has attracted considerable attention of medicinal chemists in the last few decades. Despite the very diverse pharmacologic effects ascribed to this kind of pyrimidines, there are few reports on the antioxidant evaluation of Biginelli pyrimidines. In this study synthesis of some novel Biginelli-type pyrimidines is reported. The prepa...

The oxidative cyclisation of a range of benzothieno[2,3-d]pyrimidine hydrazones (7a-e) to the 1,2,4-triazolo[4,3-c]pyrimidines (8a-e) catalysed by lithium iodide or to the 1,2,4-triazolo[1,5-c]pyrimidines (10a-e) with sodium carbonate is presented. A complementary synthesis of the 1,2,4-triazolo[1,5-c]pyrimidines (10a-e) starting from the amino imine 11 is also reported. The effect of these com...

A series of diverse furo[2,3-d]pyrimidines (2a–2b, 4a–4d and 8a–8c) benzofuro[3,2-d]pyrimidines (12a–12c) were synthesized screened for their antitumor effects against HepG2, Bel-7402 HeLa cell lines in vitro. Representatively, 4a, with an IC50 0.70 ?M, exhibited the best activity tested HepG2 lines. Molecular docking investigation further revealed possible binding modes compound 4a receptor ty...

The properties of natural, y- and yy-pyrimidines are compared using computational (B3LYP, MP2) methods. Ring expansion upon incorporation of benzene or naphthalene into the natural pyrimidines affects the preferred orientation of the base about the glycosidic bond in the corresponding nucleoside to a similar extent. Specifically, although the natural pyrimidines preferentially adopt the anti or...

Pyrimidine nucleotides represent one of the most fundamental of cellular components. They are the building blocks for the direct synthesis of DNA and RNA that function in information storage and retrieval within the cell, but they also participate in the metabolism of a large number of other cellular components from sugar interconversion to cellular polysaccharides to glycoproteins and phosphol...