Pyruvic acid is one of the most reactive substances among those of importance in cellular metabolism. When carbohydrate is split during fermentation, pyruvic acid is the main end-product of the resulting series of phosphorylated oxidation-reductions. It thus becomes the immediate source for the formation of both lactic acid and alcohol. Pyruvic acid is decarboxylated by yeast; it may react with...

A preliminary study on statistical modelling of a process for depolymerisation of cassava non-starch carbohydrate using halide salt assisted phosphoric and pyruvic acids were accomplished. The effects of three independent variables namely; acid concentration, potassium iodide salt and duration were studied using the central composite rotatable design on hydrolysis of the cassava non-starch carb...

Rita Kakkar,* Preeti Chadha, and Deepshikha Verma Department of Chemistry, University of Delhi, Delhi-110 007, INDIA Abstract Motivation. Pyruvic acid occurs naturally in the body and is the end product of the metabolism of sugar and starch. Its thermal decarboxyation reaction is important as it prevents the build-up of lactic acid in the body due to excess of pyruvic acid. However, in spite of...

~-14C]Tyrosine-labeled noniodinated hog thyroglobulin was iodinated enzymatically and nonenzymatically (iodine, iodide-chloramine-T, pH 7.4, or iodine monochloride, p.H 8.1). This led to similar levels of iodine incorporatzon as well as of thyroid hormone synthesis. Iodine monochloride at pH 5.5 formed “hormonogenic” iodotyrosine residues, but no hormone residues. The latter were formed when th...

THE literature on bacterial metabolism contains references which suggest that the anaerobic dismutation of pyruvic acid which we have shown to occur in animal tissues (see the preceding paper) may also take place in certain bacteria. Barron et al. [1932; 1933; 1934; 1936], for instance, described experiments concerning the oxidation of pyruvic acid in Gonococcus and showed that there is a speci...

Keto-enol tautomerism was investigated for ionized pyruvic acid using the DFT(B3LYP) method and the larger basis sets [6-31++G(d,p), 6-311++G(3df, 3pd) and aug-cc-pVDZ]. Change of the tautomeric preference was observed when going from the neutral to ionized tautomeric mixture. Ionization favors the enolization process (ketoenol) of pyruvic acid, whereas the ketonization (ketoenol) is preferred ...

Thiamin, acting in the form of its phosphoric ester co-carboxylase, is an enzyme necessary for the complete metabolism of glucose. In its absence glucose is broken down as far as pyruvic acid, which then accumulates until vitamin B1 is supplied. Peters and Thompson (1934) and Peters (1936) demonstrated that the respiration of avitaminotic pigeon brain was reduced as compared with that of normal...

Effect of Acephate, an organophosphorus insecticide, on tissue levels of thiamine, pyruvic acid, lactic acid, glycogen and blood sugar, has been studied. The albino rats, injected subcutaneously with Acephate (25 mg/10 gm body wt./day) for 4 weeks and 8 weeks, showed appreciable depletion of thiamine in liver, heart, kidney, brain and blood. The depletion of thiamine was found to be more after ...

Until the advent of the isotope technique, the formation of fat in adult animals was held to occur only on a diet containing an excess of calories. From the work of Schoenheimer and Rittenberg (1) it became clear that body fat is not an inert energy store but participates actively in intermediary metabolism. Their evidence also indicated that small molecules were utilized to build up the fatty ...

The discovery of the identity of thiamine pyrophosphate and cocarboxylase and the recognition of the ester as the predominant form of thiamine in yeast (1, 2) and animal tissues (3, 4) has been followed by several papers which have clearly demonstrated that cocarboxylase is essential for the oxidative metabolism of pyruvic acid (5-7). However, it has become clear that pyruvic acid is one of the...