The use of the Agilent 6540 Q-TOF LC/MS system and Agilent MassHunter software tools have enabled the identification of six new metabolites of imidacloprid by MS/MS analysis. These metabolites and their structures were deduced from MS/MS studies with accurate mass, making it possible to better understand imidacloprid metabolism in onion as well as new metabolite targets for toxicity studies.

This study investigated the changes of plasma absorbed components in rats after oral administration hederagenin. Serum pharmacochemistry analysis hederagenin was carried out to understand its metabolic body. Biological samples were collected and then migration hederagenin-containing serum established by UPLC/Q-TOF-MS technique. Possible metabolites obtained for comprehensive through relevant st...

Many kinds of venomous principles modulate physiological responses of mammalian signal transduction systems, on which they act selectively as enhancers, inhibitors or some other kind of effectors. These toxins become useful tools for physiological research. We have employed and characterized paralyzing toxins from the venom of spiders, insects and scorpions with a limited supply. We have develo...

Abstract Background Norcantharidin (NCTD) has multiple antitumor effects. However, NCTD can induce significant hepatotoxicity and the mechanism of is not clear for now. Objective This study aimed to explore in rat by ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight (Q-TOF)-MS (UPLC/Q-TOF-MS) metabolomics. Results Serum biochemical indices including alanine aminotransfera...

Abstract Bamboo leaves extract (BLE) has a variety of physiological functions such as antitumour, anti-inflammatory, antioxidant and blood fat reduction activities the flavonoids bamboo are major active constituents. To profile in complex BLE, rapid sensitive analytical method based on ultra-high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight ta...

Although mass spectrometry is making its mark on all facets of clinical laboratory medicine, arguably no field is witnessing its impact more than clinical microbiology. The application of MALDI-TOF mass spectrometry (MALDI-TOF MS) to microbial identification is revolutionizing clinical microbiology by providing rapid identification with minimal samplepreparationatapotentialsavings in costs. Acr...

Nine varieties of pigmented rice (Oryza sativa L.) seeds that were black, red, or white were used to perform metabolite profiling by using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and gas chromatography (GC) TOF-MS, to measure antioxidant activities. Clear grouping patterns determined by the color of the rice seeds were identified in pr...

The number of flavour chemicals identified in coffee has reached over 1000 [1], [2]. Coffee is one of the world's most popular beverages [3], highly studied for its health-related properties [4], [5], [6]. Studies on coffee associated with human health have focused on the negative aspects, such as the toxicity of caffeine [7], [8]. Complex chemistry happens during coffee roasting and according ...

Traditional herbal remedies are used as alternative medicines for a number of diseases. Alangium salviifolium is one such plant, used as traditional medicinal plant. Several investigations have been performed using this plant extract to demonstrate its therapeutic value. However, very few attempts have been made to identify the extensive metabolite composition of this plant. In this Application...