nature methods | ADVANCE ONLINE PUBLICATION | be subdivided into three domains (Fig. 1a) that perform specific and independent functions: the DNA-binding and dimerization domain (DBD) containing a Zn2-Cys6 motif that recognizes and binds to UAS or QUAS sites; a middle domain (MD) that has no clear function but that might be involved in endogenous regulation or stability; and a transcriptional a...

Cytomegalovirus (CMV) is a well-established cause of morbidity and mortality in pediatric recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). CD8⁺ T-cells are important for controlling CMV infection. We conducted a prospective pilot study to investigate the clinical utility of measuring the CMV-specific T-cell immune response using the QuantiFERON-CMV assay (QF-CMV) in...

The quantitative fluorescent PCR (QF-PCR) assay, introduced during the last few years, allows prenatal diagnoses of common chromosome aneuploidies in a few hours after sampling. We report the first assessment of QF-PCR performed on a large cohort of 18,000 consecutive clinical specimens analysed in two different Centres. All samples were analysed by QF-PCR using several selected STR markers tog...

In previous studies in vitro we showed that the quinone fraction (QF) from the heartwood of Auxemma oncocalyx TAUB. presented antiplatelet and antioxidant activities. In the present work, the QF antioxidant property was evaluated in models of CCl(4)-induced hepatotoxicity in rats, and prolongation of pentobarbital-induced sleeping time in mice. Our results showed that levels of plasma glutamate...

Quantitative fluorescent polymerase chain reaction (QF-PCR) is an accurate and reliable method for rapid detection of aneuploidy; however, it is not routinely used in China. We aimed to validate QF-PCR as a means for prenatal common aneuploidy screening and to analyze the heterozygosities of short tandem repeat (STR) markers in the Chinese population. The sequences of 19 STR markers in chromoso...

The purpose of this experiment was to investigate skeletal muscle blood flow and glucose uptake in m. biceps (BF) and m. quadriceps femoris (QF) 1) during recovery from high intensity cycle exercise, and 2) while wearing a compression short applying ~37 mmHg to the thigh muscles. Blood flow and glucose uptake were measured in the compressed and non-compressed leg of 6 healthy men by using posit...

We study the convexity property of the set QF of arbitrage-free prices of a multiperiod financial structure F . The set of arbitrage-free prices is shown to be a convex cone under conditions on the financial stucture F that hold in particular for short lived assets. Furthermore, we provide examples of equivalent financial structures F and F ′ such that QF is a convex cone, but QF ′ is neither c...

Objectives: The currently available methods for rapid prenatal diagnosis of common chromosomal aneuploidies are either Inter-phase-Fluorescence in Situ Hybridisation (I-FISH) or Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR). QF-PCR represents a rapid, high throughput, cost-effective alternative for Interphase-FISH. The objective of the study was to evaluate the performance of QF-P...

The Faith-Menal conjecture says that every strongly right Johns ring is QF . The conjecture is also equivalent to say every right noetherian left FP -injective ring is QF . In this short article, we show that the conjecture is true under the condition( a proper generalization of left CS condition) that every nonzero complement left ideal is not small( a left ideal I is called small if for every...