Copper(II) acetate/acetic acid/O2 and potassium iodide/tert-butylhydroperoxide systems are shown to affect the selective oxidation of ring-fused aminals to dihydroquinazolines and quinazolinones, respectively. These methods enable the facile preparation of a number of quinazoline alkaloid natural products and their analogues.

The quinazolinone nucleus represents, among the class of fused heterocycles, a very important scaffold to obtain molecules with biological activities. A review literature revealed how such kind coming from natural or synthetic source, are associated wide range This is mainly directed towards 4-(3H)-quinazolinones N-3 substituted five membered heterocycle in which all possible combinations nitro...

BACKGROUND Quinazolinon as an important class of heterocycles is attractive in medicinal research areas due to their wide range of biological effects. Cytotoxic activities of the quinazolinone derivatives in various cell lines including: HeLa, L1210 (mouse lymphocytic leukemia) and HT29 (human colon adenocarcinoma) were reported. MATERIALS AND METHODS In this study, a number of newly made tri...

A facile and highly efficient protocol was applied successfully to synthesize 4H-pyrimido[2,1,b]benzimiazoles and 4H-pyrimido[2,1,b]benzothiazoles through one-pot three-component cyclocondensation reactions of 2-aminobenzimidazole or 2-aminobenzothiazole with dimedone and aromatic aldehydes in the presence of guanidinium chloride under solvent-free conditions. The reactions us...

objective(s) quinazolinones are heterocyclic components (able to form cyclized compounds) which have several medical effects such as anti-malarial, spasmolytic, anti-microbial, sedative, etc. they are also known for their fungicidal properties, inhibition of tyrosine-kinase and dna repair enzyme poly (adp-ribose) polymerase (parp) and are also effective in treatment of cancer, diabetes, and par...

quinazolinone backbone is present in a large number of bioactive substances. since remarkable cytotoxic activity is associated with some 4(3h)-quinazolinones, in this study some 4(3h)-quinazolinone were synthesized and screened against hela cells. the synthesis was performed via reaction of anthranilic acid with dicarboxylic anhydrides to produce carboxylic acids derivatives. the products were ...