Luotonins are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types. Luotonins A, B, and E are pyrroloquinazolino-quinoline alkaloids, luotonins C and D are canthin-6-one alkaloids, and luotonin F is a 4(3H)-quinazolinone alkaloid. All six luotonins have shown promising cytotoxicities towards selected human cancer cell lines, especially against l...

Skimmia laureola Hook (Rutaceae) is found in Kashmir and in the mountains of Northern Pakistan and is used in folklore medicine for the treatment of various ailments [1 – 3]. The quinoline alkaloids of this plant have demonstrated antifungal and immunomodulating properties [4, 5]. The ethanolic extracts of the aerial parts of S. laureola are active against the animal pathogen Microsporium canis...

Pyranoquinoline alkaloids, which possess inter­ esting pharmacological properties are known [1, 2] to occur in the plant family Rutaceae. The alka­ loids, khaplofoline (1) and ribalinine (2), isolated respectively from Haplophyllum foliosum (Vved) [3] and Balfourodendron riedelianum [4], members of the rutaceae, are structurally proven to be of pyrano [2,3-b]quinoline systems. Several reports h...

The quinoline methanol antimalarial drug mefloquine is a structural analogue of the Cinchona alkaloids, quinine and quinidine. We have elucidated the single crystal X-ray diffraction structure of the complexes formed between racemic erythro mefloquine and ferriprotoporphyrin IX (Fe(iii)PPIX) and show that alkoxide coordination is a key interaction in the solid-state. Mass spectrometry confirms ...

A derivative of quinine formed in minced rabbit liver has been isolated by Kelsey et al. (I), and identified by Mead and Koepfli (2) as a carbostyril. Hence quinine is oxidized in liver with replacement of the hydrogen atom in position 2 of the quinoline ring by a hydroxy group. Analogous oxidation products are excreted by men receiving the four principal cinchona alkaloids. This change is impo...