Phyllanthus amarus Schum. and Thonn., a widely distributed annual medicinal herb has a long history of use in the traditional system of medicine for over 2000 years. However, the lack of genomic data for P. amarus, a non-model organism hinders research at the molecular level. In the present study, high-throughput sequencing technology has been employed to enhance better understanding of this he...

OBJECTIVE To determine the antioxidant activity and cytotoxicity of Phyllanthus virgatus crude extract compared to Phyllanthus amarus. METHODS Phenolic contents of the hydromethanolic extracts were measured using Folin-Ciocalteu reagent. Antioxidant activity was evaluated by the 2,2-diphenyl-1-picrylhydrazyl hydrate free radical scavenging and antilipid peroxidation assays. Cytotoxicity on hu...

Present investigation was aimed at formulation, characterization and evaluation of phytosomal complex tablets for sustained delivery of Phyllanthus amarus complex. Phyllanthin, one of the active lignin present in this plant species was isolated from the aerial parts, by silica gel column chromatography employing gradient elution with hexane–ethyl acetate solvent mixture. It was obtained in high...

BLACK Natural Product Radiance 218 Nelumbo nucifera Gaertn. (Hindi ⎯ Kamal) is a perennial aquatic crop, grown and consumed throughout Asia. Its parts have been used for various medicinal purposes in oriental medicine. In particular, the leaves are known for diuretic and astringent properties, and are used to treat fever, sweating, and strangury and as a styptic. Kashiwada and others during the...

A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7'-oxocubebin dimethylether (1,4-bis(benzo[d][1,3]dioxol-5-yl)-2,3-bis(methoxymethyl)butan-1-on). The non-transformed root cultures of P. amarus showed to be a selective ...

The present study was aimed at evaluating the antifertility effect of phyllanthus amarus extract in male wistar rats. The body and organ weights, cauda epididymal sperm parameters, serum levels of male reproductive hormones and fructose were assessed. Daily oral doses of the extract were administered to each animal in three different test groups for 28 consecutive days. Results show significant...

General phytochemical screening of Phyllanthus amarus (Euphorbiaceae) revealed the presence of Saponin, tannins, glycoside and alkaloids etc. The aim of this study is to identify and characterize the bioactive principle from the plant. It has wide folk medicinal uses. The isolation and characterization of Phytoconstituents was done from the methanolic extract by the gradient fractionation metho...

Histological studies of the effects of oral administration of aqueous extract of Phyllanthus amarus commonly used in ethno medical practice in Africa for the management of various ailments such as kidney stones, dysentery, jaundice, diarrhoea and urogenital diseases on the kidney of adult Wistar rats were carefully studied. Rats of both sexes (n=24), average weight of 260g were randomly assigne...

Impact of Phyllanthus amarus extract on antioxidant enzymes in Drosophila melanogaster N. Manasa, J. S. Ashadevi

In the present study, leaves of Ocimum sanctum, Azadirachta indica and Phyllanthus amarus were collected and the collected leaves were shade dried and powdered by hand crushing. The preparations of different leaves extract was done through modified method. Three different solvents viz., methanol, chloroform and ethyl acetate were used to study the antimicrobial activity of herbal plants. Disc d...