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Cain, Delver R., Van De Velde, Robert, and Shapiro, Stephen J.: Spironolactone inclusions in an aldosteronoma. Am. J. Clin. Pathol. 61: 412-416, 1974. Spironolactone cytoplasmic inclusions were found in an aldosteronoma but not in the adjacent zona glomerulosa of an adrenal gland that was removed because of aldosteronism. Their light and electron microscopic appearance was similar to that of pr...

AMG 416 is a novel D-amino acid-containing peptide agonist of the calcium-sensing receptor (CaSR) that is being evaluated for the treatment of secondary hyperparathyroidism in chronic kidney disease patients receiving hemodialysis. The principal amino acid residues and their location in the CaSR that accommodate AMG 416 binding and mode of action have not previously been reported. Herein we est...

A novel peptide, AMG 416 (formerly KAI-4169, and with a United States Adopted Name: velcalcetide), has been identified that acts as an agonist of the calcium-sensing receptor (CaSR). This article summarizes the in vitro and in vivo characterization of AMG 416 activity and the potential clinical utility of this novel compound. AMG 416 activates the human CaSR in vitro, acting by a mechanism dist...

AMG 416 is a novel D-amino acid–containing peptide agonist of the calcium-sensing receptor (CaSR) that is being evaluated for the treatment of secondary hyperparathyroidism in chronic kidney disease patients receiving hemodialysis. The principal amino acid residues and their location in the CaSR that accommodate AMG 416 binding and mode of action have not previously been reported. Herein we est...

Background: Sagittal imbalance is known as the main radiographic driver of disability in adult spinal deformity (ASD).In this study, the association of radiological spinopelvic parameters and clinical outcomes was evaluated following thecorrective surgery of sagittal imbalance, in order to explore the predictive ability of each parameter.Methods: A total of 23 patients, who underwent corrective...

0957-4174/$ see front matter 2013 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.eswa.2013.12.027 ⇑ Corresponding author. Tel.: +91 416 2202364; fax: +91 416 2243092. E-mail addresses: [email protected] (M. Monica Subashini), sksahoo@ vit.ac.in (S.K. Sahoo). 1 Tel.: +91 416 2202467; fax: +91 416 2243092. 2 Abbreviations used: PCNN, pulse coupled neural networks; ICM, i...