While human and other mammals are limited in their abilities to regenerate, amphibians, including salamander species such as the axolotl (Ambystoma mexicanum), highly regenerative. Contrary prevailing notion that healing via embryonic-like regeneration necessarily requires a specialized “blastema” tissue, we show axolotls regenerate new skin with anatomically complex secretory glands without bl...

A recent study reported that Botulinum toxin type A (BTXA) could inhibit the growth of hypertrophic scars and improve their appearance. However, the mechanism of BTXA's action on hypertrophic scars is still unknown. Some in vitro studies had shown BTXA could alleviate hypertrophic scars by acting on the biological behavior of fibroblasts, but there are few in vivo experiments, especially animal...

Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the devoid of blastema (dob) mutant that fails fin regeneration during initial steps, forms abnormal regeneration epithelium, and does not form blastema. This mutation has no impact on e...

Extracellular cathepsin D has been demonstrated immunohistochemically in cultured chicken and rabbit cartilage. Enzyme released from viable cells was captured by specific anti-cathepsin D antibody to form extracellular immunoprecipitates which were demonstrated with fluoresceinlabelled antibodies. In unfixed frozen sections these immunoprecipitates could be dissolved in antigen excess, and clos...

BACKGROUND AND OBJECTIVE The onset and progression of pathological scarring involves multiple cytokines and complex mechanisms. However, hyperplasia of fibroblasts and neovascularization plays important roles, which can be inhibited by paclitaxel. The aim of this study was to investigate the efficacy of paclitaxel in the treatment of hypertrophic scars on rabbit ears. METHODS Rabbit ear model...

KLUGER, MATTHEW J., RICHARD R. GONZALEZ, AND JAMES D. HARDY. Peripheral thermal sensitivzty in the rabbit. Am. J. Physiol. 222(4): 1031-1034. 1972.-Selective warming of the ears of the New Zealand white rabbit at ambient temperature (TEL) of 8 C led to a decline in metabolism (M) and no significant change in hypothalamic temperature (Thy). After ear warming was discontinued, M increased. Conver...

OBJECTIVE This study is designed to explore permeability of ethosomes encapsulated with 5-florouracil (5-FU) mediated by CO2 fractional laser on hypertrophic scar tissues. Moreover, therapeutic and duration effect of CO2 fractional laser combined with 5-FU encapsulated ethosomes in rabbit ear hypertrophic scar model will be evaluated. METHODS The permeated amount of 5-FU and retention content...

The alpha-1L adrenoceptor (AR) was identified in rabbit ear artery by both functional and ligand binding studies. In functional studies using arterial rings, the contractile response to NS-49 [(R)-(-)-3'-(2-amino-1-hydroxyethyl)-4'-fluorometh-anesulfonanilide hydrochloride] (alpha-1A and alpha-1L AR-selective agonist) was competitively antagonized with low affinities by prazosin, RS-17053 [N-[2...