objective: electro-magnetic radiation (emr) is emitted from mobile phones. various researches have shown relationships between mobile phone emr exposure to cancer and neurologic damages. this study aims to investigate the effects of mobile phone emr on brain antioxidant enzyme activity and the learning process. methods: rat pups and their dames were exposed to emr for 3 h per day from p2 to p1...

Halakhor S1, Qujeq D2, Shikhpour R3 1. Instructor, Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran 2. Associate professor, Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran 3. GP, Babol, Iran Abstract Background: Previous reports show that phosphorylation anddepho...

In type 2 diabetes mellitus (DM2), the impaired functions of brain insulin system are associated with weakened transport through blood-brain barrier due to resistance. Insulin deficiency in can be corrected by intranasal administration (II), whose effect may enhanced C-peptide (ICP). this work, we study treating hyperinsulinemic and normoinsulinemic DM2 rats ICP (36 µg/rat/day), II (20 µg/rat/d...

Evaluating the impact of Viola spathulata in a rat model brain ischemia/reperfusion by influencing expression level caspase-3 and cyclooxygenase-2

This study aimed to observe the protective effects of sufentanil pretreatment on rat cerebral injury during cardiopulmonary bypass (CPB) and to explore the underlying mechanism. Twenty-four male adult Sprague Dawley (SD) rats were divided into 4 groups. Then, the rat CPB model was established. A 14G trocar was inserted into the atrium dextrum. For rats in S1 and S5 groups, sufentanil (1 µg•kg-1...

This study aimed to observe the protective effects of sufentanil pretreatment on rat cerebral injury during cardiopulmonary bypass (CPB) and to explore the underlying mechanism. Twenty-four male adult Sprague Dawley (SD) rats were divided into 4 groups. Then, the rat CPB model was established. A 14G trocar was inserted into the atrium dextrum. For rats in S1 and S5 groups, sufentanil (1 µg•kg-1...

Introduction: Recent studies suggest that dietary virgin olive oil (VOO) reduces hypoxia-re oxygenation injury in rat brain. We have attempted to determine the effect of dietary virgin olive oil on brain lipidomics and its relationship with brain edema in a rat stroke model. Methods: Five groups, each consisting of 6 male Wistar rats, were studied. The first and second groups (control and s...

Neurosteroids are steroids that are produced in the central nervous system (CNS). While progesterone and dehydroepiandostendione (the precursors of testosterone) are among the identified neurosteroids, it is not clear that testosterone could be considered as a neurosteroid. The testosterone synthesis has been demonstrated in the brain of castrated frog, but not in the rat brain. In the present ...

Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. These vesicles are secreted from various cells such as mesenchymal stem cells (MSCs) and can pass through biol...

Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. These vesicles are secreted from various cells such as mesenchymal stem cells (MSCs) and can pass through biol...