In locally advanced rectal cancer, preoperative chemoradiotherapy (pCRT) is the standard care, aiming at downstaging and downsizing tumor prior to potential radical surgery (1, 2). However, response pCRT highly variable, with only 8-20% of patients exhibiting a complete pathological (3). Surgical resection rectum may be associated significant morbidity mortality. Moreover, surgical not lead inc...

Laparoscopic total mesorectal excision (LaTME) following preoperative chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC) is technically demanding. The present study intended to evaluate predictive factors of surgical difficulty LaTME PCRT by using pelvimetric and nutritional factors. Consecutive LARC patients receiving after were included. Surgical was classified based upon intra...

BACKGROUND The objectives of this study were to investigate the predictive value of sequential (18)F-FDG PET scans for pathological tumor response grade (TRG) after preoperative chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC) and the impact of partial volume effects correction (PVC). METHODS Twenty-eight LARC patients were included. Responders and non-responders status were ...

Background: Postoperative chemotherapy (pCT), together with chemoradiotherapy (pCRT), is well used for the treatment of squamous cell carcinoma in esophagus. However, these adjuvant therapies may cause serious adverse effects resulting higher postoperative morbidity.
 Methods: In this study, we aim to assess and compare cardiopulmonary complications as a result pCT pCRT patients esophageal...

Good oncologic outcomes, demonstrated by a complete pathologic response after preoperative chemoradiotherapy (PCRT), have led to local excision (LE) in selected patients with rectal cancer. We evaluated the oncologic safety of LE compared with total mesorectal excision (TME) in patients with ypT0-T1 rectal cancer.A retrospective review of 304 patients who underwent PCRT, followed by LE or TME, ...

Numerous evidence suggests that interneurons located in the lateral tegmentum at the level of the trigeminal motor nucleus contribute importantly to the circuitry involved in mastication. However, the question of whether these neurons participate actively to genesis of the rhythmic motor pattern or simply relay it to trigeminal motoneurons remains open. To answer this question, intracellular re...

Studies regarding preoperative nutritional and immunologic status have increased. The prognostic nutritional index (PNI) calculated based on the serum albumin concentration and the total lymphocyte count was initially suggested for assessing the influence of the perioperative immunonutritional status on surgical risk [1]. Recently, studies have reported an association of the PNI with oncologic ...

Summary Background/objective Some locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (CRT) prior to total mesorectal excision (TME) show early recurrence a short disease-free interval. This is unacceptable for and their families, necessitating re-evaluation of the treatment process. We aimed evaluate risk factors prognostic impact in who received preoperat...

BACKGROUND Therapeutic management of Locally Advanced Rectal Cancer (LARC) involves pre-operative chemoradiotherapy (pCRT) followed by surgery. However, after pCRT the complete pathological response is approximately 20%, whereas in 20 to 40% of patients the response is poor or absent. METHODS Cancer biopsy specimens (n= 38) and serum samples (n= 34) obtained before pCRT from 38 LARC patients ...

The purpose of the present study was to identify vagal subnuclei that participate in reflex swallowing in response to electrical stimulation of the left superior laryngeal nerve (SLN). SLN stimulation at 10 Hz evoked primary peristalsis, including oropharyngeal and esophageal peristalsis, and LES relaxation. It also induced c-fos expression in interneurons in the interstitial (SolI), intermedia...